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Membrane and Action Potential
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What is a potential difference?
A charge separation across a cell membrane - a difference (delta) in volts (V). Measured in mV
Outside is more positive
Inside is more negative
Calculated for one ion species by the Nernst equation.
How does charge separation arise?
Transmembrane concentration differences
and
the presence of leak ion channels
What is conductance?
Leakiness
Conductance (Gion) = measure of the ease with which an ion can cross a unit area of 1cm2 of membrane
=Po n gamma
Po is the probability the channel is open
n is the number of channels
gamma is the number of ions per second that a chanel can conduct
If Po = 1, then channels are open all the time and are therefore "leak" channels
How do we calculate the resting membrane potential?
The Goldman Equation
This takes into account the conductance of the K, Na and Cl and their equilibrium potential, sums it and this = Vm (AKA RMP)
Author
Anonymous
ID
19434
Card Set
Membrane and Action Potential
Description
membrane action potential Rosemay Martin
Updated
2010-05-16T13:11:14Z
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