pharma

• 1.antiarrythmic.antimuscarinic,alpha blocker.
• 2.initial digitalisation required for AF
• 3.adv:cinchonism:tinnitus headache ocular G.I.dysfunction torsades.
• 4.displace digoxin frm tissuebindin sites
•    hyperkalemia enchances effect

antiarrythmic,hapten,metabolised by acetylization,binds to tissueproteins(SLE like syndrome),hematoxicity,torsades.

• hydralazine
• isoniazid
• procanamide
• antihistones more specific

• post MI
• digoxin toxicity
• openheartsurgery
• advrse;;;seizures,least cardiotoxic
• always used i.v...so oral drugs in dis class are mexiletine,tocainide.

• last resort in refractory cases
• potent proarrythmic so not much used.