-
any abnormal change in the function or structure of the body as a result of some type of injury:
disease
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sequence of events producing cellular changes that lead to observable changes known as manifestations:
pathogenesis
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the term to describe how the disease presents itself:
manifestation
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the study of disease processes:
pathology
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the patient's perception of the disease that has subjective manifestations:
symptom
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an objective manifestation that can be detected by the physician during examination:
sign
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a group of signs and symptoms that characterizes a specific abnormal disturbance.
syndrome
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the study of the cause of a disease:
etiology
-
a term used when no cause for disease can be identified:
idiopathic disease
-
a disease that is acquired from the environment of the hospital:
nosocomial disease
-
adverse responses that occur from medical treatment itself:
iatrogenic
-
a disease that has a quick onset and last a short period of time:
acute disease
-
a disease that occurs more slowly and lasts a very long time:
chronic disease
-
the name of the disease:
diagnosis
-
the prediction of the course and outcome of the disease:
prognosis
-
lasting side effects from having an acute illness:
sequelae
-
description of a disease process in which there is decrease in body tissue density:
- destructive/lytic/subtractive
- (the atomic number of the tissue cells decreases or the compactness of the tissue cells decreases, or atrophy occurs from limited use)
-
Body tissue is altered by increasing the normal tissue density.
- additive/sclerotic disease process
- (atomic number is increased or compactness of cells increases)
-
diseases that produce lesions that are similar in form and structure:
morphology
-
the investigation of disease in large groups:
epidemiology
-
the number of cases of a disease found in a given population:
prevalence
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the number of new cases of a disease found in a given time period:
incidence
-
diseases of high prevalence in an area where a given causative organism is commonly found:
endemic
-
give the example we used for an endemic:
histoplasmosis is endemic to the Ohio and Mississippi River valleys
-
excessive prevalence or an outbreak of disease in the same geographical area:
epidemic
-
a widespread epidemic, that is, a disease or outbreak that affects very high proportions of the population, or populations throughout the world:
pandemic
-
The number of deaths caused by a particular disease averaged over a population:
mortality rate
-
the incidence of sickness sufficient to interfere with an individual’s normal daily routine:
morbidity rate
-
tracks, monitors, and reports trends in health and aging and responsible for trending morbidity rates:
- CDC (center for disease control and prevention)
- reports to the NCHS
-
collects death certificates from each state and publishes information on mortality statistics and trends:
NCHS (the nation center for health statistics)
-
monitors and reports mortality rates in terms of leading causes of death, according to sex, race, age, and specific causes of death such as heart disease or breast cancer:
- NCHS (the nation center for health statistics)
- DHHS (U.S. department of health and human services)
-
leading causes of death in the US are _________ diseases. name the top two.
- chronic
- heart and malignant neoplasms
-
over the past nine years, mortality rates have declined for:
-
mortality rates are on the rise for:
- hypertension
- Alzheimer's disease
-
mortality info comes from ________________ and statistics can be affected by:
- death certificates
- how causes of death are coded
-
an international coding system or standard diagnostic classification system used to report causes of death:
tenth revision, international classification of diseases (ICD-10)
-
used to classify diseases and other health problems and is recorded on many types of health and vital records including death certificates and health records:
tenth revision, international classification of diseases (ICD-10)
-
the total value of goods and services produced in a country over a period of time:
GDP (gross domestic product)
-
In 1998 U.S. health spending accounted for _______ of gross domestic product, a larger share than in any other major industrialized country.
16%
-
how much were health care expenditures in 2004?
1.9 trillion
-
the project coordinated by the US department of energy (DOE) and the national institutes of health (NIH) to identify all 20,000 to 25,000 genes in human DNA:
the human genome project (1990-2003)
-
be familiar with the applications of genome research:
- Improved diagnosis of disease
- Earlier detection of genetic predispositions to disease
- Gene therapy
- Newborn screening
- Customized therapeutics
- DNA forensics
-
list the six disease classifications:
- congenital and hereditary
- inflammatory disease
- degenerative disease
- metabolic disease
- traumatic disease
- neoplastic disease
-
present at birth, genetic or environmental causes:
congenital
-
developmental disorders passed down from parents/ancestors:
hereditary
-
results from the body’s reaction to a localized injurious agent. Internal or external agents destroy cells or cause the body to injure itself through the inflammatory process:
inflammatory disease
-
a type of inflammatory disease stemming from invasion by microorganisms such as viruses, bacteria, or fungi:
infective diseases
-
a type of inflammatory disease which results from poisoning by biologic substances:
toxic disease
-
a type of inflammatory disease that is an overreaction of the body’s own defenses:
allergic disease
-
a type of inflammatory disease in which antibodies are formed and act against and injure that patient’s own tissues:
- autoimmune disorders
- (ex. lupus, rheumatoid arthritis)
-
a generalized pathologic process that is nonspecific to the agent causing the injury:
inflammatory reaction
-
with an inflammatory reaction, substances released from the damaged tissues can cause:
both local and systemic effects
-
clinical symptoms of acute inflammation:
- red skin (rubor)
- swelling (edema)
- heat at site (calor)
- pain (dolor)
- some loss of function as the body tends to protect the injured part
- system effects, such as fever, can occur if the inflammatory process is significant
-
damage caused by an injurious agent may not necessarily result in tissue death:
chronic infection
-
when it comes to tissue regeneration, what type of cell doesn't normally replace itself?
damaged nerve cells
-
________________________ is the alternative to regeneration, this leads to:
- fibrous connective tissue repair
- scarring and fibrosis
-
removal of dead cells and materials:
debridement
-
replication of the cells via mitosis to fill in the tissues includes:
- capillaries
- fibroblasts
- collagen
- elastic fibers
-
an inflammatory process caused by a disease-causing organism where the pathogenic agent multiplies and causes injurious effects:
infection
-
refers to the ease with which an organism can overcome the body’s defenses:
virulence
-
a type of disease in which the function or structure of the tissue deteriorates; process usually occurs with aging, but can occur in younger individuals, for example after an injury.
degenerative disease
-
the physiologic processes reach a peak, and gradually fade (degenerate) until the body can’t survive:
the aging process
-
factors affecting the aging process:
- heredity
- diet
- environmental
-
diseases common with aging:
- atherosclerosis (hardening of the arteries)
- osteoporosis
- osteoarthritis
-
radiographic indication of osteoarthritis:
bone spur (osteocyte)
-
diseases caused by a disturbance of the normal physiologic function of the body:
metabolic diseases
-
the sum of all physical and chemical processes in the body:
metabolism
-
give some examples of metabolic diseases:
- endocrine disorders –
- diabetes
- hyperparathyroidism
- altered fluid and electrolyte balance
-
metabolic functions are regulated by:
hormones secreted by endocrine glands
-
list major endocrine glands:
- pituitary gland
- thyroid gland
- parathyroid glands
- adrenal glands
- pancreatic islets
- ovaries
- testes
-
mineral salts dissolved in the body’s water:
electrolytes
-
two examples of electrolytes:
-
causes of electrolyte imbalance:
- vomiting
- diarrhea
- diuretics
-
the most common disturbance of fluid balance, due to insufficient intake of water or excessive loss of water:
dehydration
-
disturbance of either fluid or electrolyte balances upset __________ , the body’s normal internal resting state:
homeostasis
-
a disease classification that may result from mechanical forces, effects of ionizing radiation, hot or cold temperatures:
traumatic diseases
-
an injury of soft parts associated with rupture of the skin:
wound
-
bleeding into the tissue spaces as a result of capillary rupture:
bruise/contusion
-
disease classification caused by alterations in cell growth, resulting in new, abnormal tissue growth:
neoplastic disease
-
the many types of cellular change that can occur in response to disease:
lesion
-
results from overgrowth of cells, they can be benign or malignant:
neoplasm or tumor
-
a general term denoting various types of malignant neoplasms:
cancer
-
when differences between the new cells and the original cells are small, the growth is termed:
differentiated
-
If cells have atypical characteristics, they are considered _____________________ and have a high probability of malignancy.
poorly differentiated/undifferentiated
-
the spread of cancer cells:
metastasis
-
the spreading of cancer cells by the blood stream:
hematogenous spread
-
the spreading of cancer cells by the lymphatic system:
lymphatic spread
-
the spreading of cancer cells into surrounding tissue because of close proximity of the area:
invasion
-
cancer cells travel to a distant site or distant organ system:
seeding
-
one type of cancer and is derived from epithelial tissue, this is not the same as the general term cancer:
carcinoma
-
a cancer which arises from connective tissue:
sarcoma
-
cancer which arises from blood cells:
leukemia
-
cancer which arises from lymphatic cells:
lymphomas
-
benign and malignant tumors are named according to:
the tissue type of origin
-
name three treatments of cancer:
- surgery
- chemotherapy
- radiation therapy
-
the type of cancer treatment depends on:
- the type of cancer
- location of the cancer
- the stage of the cancer
- the oncologist
-
treatment that allows the patient to remain free of disease for five years or more:
curative
-
treatment which is designed to relieve pain when curing is not possible:
palliative
-
a classification used to determine the appropriate treatment and also, helps in determining prognosis:
staging of cancer
-
know the following tumor root words:
adeno
angio
chondro
fibro
hemangio
lipo
myo
neuro
osteo
- adeno: gland
- angio: vascular
- chondro: cartilage
- fibro: fibrous tissue
- hemangio: blood vessels
- lipo: adipose tissue
- myo: muscle
- neuro: nerve
- osteo: bone
-
a system endorsed by the American Joint Committee on Cancer (AJCC) used to stage cancer:
TNM system:
- T represents the size of the untreated, primary tumor
- N is the lymphnode involvement
- M is the metastasis of the lesion
-
be familiar with the TNM grading system:
- T0: no evidence of primary tumor exists
- T1-T4: indicate an increasing size and extension of the tumor
- N0: indicates lack of regional lymph node metastasis.
- N1-N3: indicate increasing involvement of regional lymph nodes
- M0: indicates no distant metastasis
- M1: indicates distant metastasis
-
additional categorization of tumors, past the TNM system, based on:
- the tumors primary site
- histopathologic type and grade
- lymphatic or venous invasion
- residual tumor classification
-
neoplastic cells are examined histologically, and these growths are categoized or “graded” according to:
- their degree of differentiation
- (grade 1 is the least malignant, grade 4 is the most malignant)
-
generalized decrease in cell size:
atrophy
-
a generalized increase in cell size:
hypertrophy
-
absence of tumor cell differentiation, loss of cellular organization:
anaplasia
-
an increase in the number of cells in tissues as a result of excessive proliferation:
hyperplasia
-
abnormal transformation of a specific differentiated cell into a differentiated cell of another type:
metaplasia
-
abnormal changes of mature cells:
- dysplasia
- also called atypical hyperplasia
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