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What are the five cardinal signs of inflammation?
- Redness
- Hotness
- Swelling
- Pain
- Loss of function
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What cardinal sign is caused by fluid release, chemicals, biproducts, and microirritations
Pain
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What are the three events of acute inflamation?
- 1. Vasodilation
- 2. Vascular leakage and edema
- 3. Leukocyte emigration (phagocytosis)
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What occurs briefly before vasodilation?
vasoconstriction
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What acute inflammation event causes warmth / redness, opens microvascular bed, and increases the intravascular pressure
Vasodilation
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Where does fluid build up during edema?
between cell and tissue
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what type of vascular leakage does inflammation cause?
Exudate release
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What would be seen in fluid the is released due to exudate release?
- High Density fluid
- immunoglobins
- leukocytes
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What do histamines, bradykinins, and leukotrienes cause and in what stage of inflammation?
- Immediate transient endothelial cell contraction
- During first 15 to 30 min of vascular leakage (in vanules only)
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What is it called when when leukocytes move toward gap in endothelium?
margination and rolling
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What mediates early rolling adhesion?
- E-Selectin (endothelium)
- P-Selectin (platelets)
- L-Selectin (leukocytes)
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What are the first white blood cells to transmigrate (Diapedesis)
Polymorphic Neutrophils (PMN) (phagocytes)
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What cells recognize what needs to be attacked?
T-Lymphocytes
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What cells build the immunolgobin.
B-Lymphocytes
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What are cytokines, LTB4, Soluble bacterial products, complement component C5
Chemotaxis
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What chemotaxis are used to communicate between cells?
Cytokines
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