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Route for Metoclopramide (Reglan)
- IV
- IM
- PO
- 1-2mg/kg(30 min prechemo, repeat q2h*2dose, then q3h*3doses)
- 10-20mg *1, end of surgery
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MOA of metoclopramide(Reglan)
Blocks dopamine in chemreceptor zone→CTZ desensitized to GI impulses,stimulates peristalsis, enhances stomach emptying
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Class of metoclopramide(Reglan)
- Antiemetic
- Prokinetic
- Dopamine antagonist
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Indications for metoclopramide(Reglan)
- Tx delayed gastric emptying
- GERD
- N&V
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Contraindications of metclopramide(Reglan)
- Seizure disorder
- Pheochromytoma
- Breast Ca
- GI obstruction
- Pt w/allergy to procaine/ procainamide
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Adverse effects of metoclopramide(Reglan)
- Extrapyramidal adverse effects in youths Cardio-hypotension, supraventricualar tachycardia,
- CNS- sedation, fatigue, restless, HA, dystonia
- GI- dry mouth, N&V, diarrhea
- *tardive dyskinesia w/long term use
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Interactions of metoclopramine(Reglan)
- Alcohol-additive CNS depression
- Antocholinergics & analgesics- block motility effects
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