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Routes for famatodine(Pepcid)
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MOA of famotadine(Pepcid)
- Blocks H2 receptor on parietal cells→less response of parietal cells to histamine, Ach,
- and gastrin→reduced H+ ion secretion from parietal cells and increased pH of
- stomach
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Class of famotidine(Pepcid)
- Acid-control
- Selected H2 receptor antagonist
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Indications for famotidine(Pepcid)
- Dyspepsia
- Heartburn
- Ulcers
- Pathological hypersecreation
- GERD
- adjunct for GI bleeds
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Contraindications for famotidine(Pepcid)
- Allergy
- Liver/kidney disfunction
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Side effects of famotodine(Pepcid)
- Thrombocytopenia
- Increased prolactin secreations
- Hypotension(IV use)
- HA, confusion, slurred speech
- Diarrhea, nausea, abd cramps
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Interaction
- Inhibits absorption of some drugs
- Smoking decreases effectiveness
- Take 1-2 hours before antacids
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