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What is the med class for lovastation(Mevacor), atrovastatin ( Lipitor), and simvastatin (Aocor)
- Antilipemic
- HMG-CoA reductase inhibitor
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What are the indications for lovastatin, atrovastatin, and simvastatin
- Types IIa/IIb Hyperlipidemia
- Hypercholesterolemia
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How does Mevacor, Lipitor, and Zocor work
Block the enzyme HMG-CoA which is needed to synthesize cholesterol in liver
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Which statin is the most effective to lower triglycerides
atrovastatin(Lipitor)
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Contraindications of lovastatin(Mevacor), atrovastatin(Lipitor), simvastatin(Zocor)
- Allergy
- Pregnancy
- Liver disease
- Elevated liver enzymes
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Side effects of lovastatin(mevacor), atrovastatin(Lipitor), simvastatin(Zocor)
- CNS-HA, dizzy, blurred vision, fatigue, nightmares,insomnia
- GI-constipation, diarrhea, nausea, bowel changes, GI upset
- Other-myalgias, rash, myopathy (rhabdomyolysis)
- Renal damage
- Elevation of liver enzyme(monitor)
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Interactions w/lovastatin(Mevacor), atrovastatin(Lipitor), simvastatin(Zocor)
- Grapefruit juice
- anticoagulants
- Antilipemic
- antidiabetic, insulin
- Erythromiacin
- Niacin
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How long for S&S to improve when taking lovastatin, atrovastatin, simvastatin
6-8wks
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How does lovastatin(Mevacor) atrovastatin(Lipitor) and simvastastin(Zocor) effect cholesterol levels
- ↓LDL 30-40%
- ↑ HDL 2-15%
- ↓Triglycerides 10-30%
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Which drug is the most effective at lowering triglycerides
atrovastatin(Lipitor)
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What is the route for lovastatin(Mevacor), atrovastatin(Lipitor), and simvastatin(Zocor)
PO
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