Traditionally, how many clinical evaluations are suspected autoimmune patients subjected to?
How many develop B-cell lymphomas?
10% develop B cell lymphoma
How long do the 6 clinical tests for autoimmune diseases take?
It takes two weeks, costing $2000
Which biomarkers are in primary Sjogren's patients?
17 Candidate salivary proteomic biomarkers
8 transcriptomic biomarkers
How often do you conduct salivary diagnostics on suspected autoimmune patients?
Every 3 months
What are the two NIDCR initiatives for salivary diagnostics?
1. Technology development
2. Salivary proteome
What is Her-2-neu?
A breast cancer marker that is found in saliva
How do biomarkers enter the saliva?
From capillary beds that enter into the luminal space
How many proteins are located in saliva?
Head and neck Cancer
350,000 new cases yearly
HNSCC <40% survival rate
What should we do if we see something unusual in the oral cavity? And then?
Send the patient away for a few weeks and call them back
If it's still there then you biopsy
How many people that receive traditional biopsies are cancer free?
96% Are cancer free
Can RNA exist outside of cells?
Many are encapsulated within the exosome
What is the pathology of Sjogrens syndrome?
Lymphocyte infiltration of salivary and lacrimal glands
Causes dry mouth and eyes
What percentage of dentists are willing to collect oral fluids for diagnostics?
Oral pathology 2