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Leukocyte adhesion deficiency
CD18 - can't tightly bind and get out of blood stream.... no abscess and pus formation.... first sign umbilicus does not fall off
Lymphoid signal
IL-7
Myeloid signal
IL-3
First antibody to be made
IgM
CD 19 and CD 21
B cells
CD 3
T cells
Substances chemoattractive to neutrophils
IL-8 C5a fibriopeptides leukotriene B4 and formyl methionyl peptides
phagocytosis enhanced by
c3b
Chronic granulomatous disease
deficiency of NADPH oxidase - recurrent infection with cat + organisms
inflammatory cytokines
Il-1, Il-6 and TNF-alpha
act as superantigens
staph enterotoxins, TSST-1 and strep pyrogenic exotoxins
Encourage TH1 reaction
IL-12
+ feedback to continue TH1 response
IFN-gamma (which also inhibits TH2 response
Encourage TH2 response
IL-4
+ feedback to continue TH2 response
IL-4 (and inhibits TH1 response)
Author
Anonymous
ID
19025
Card Set
Immuno
Description
from comlex book
Updated
2010-05-12T17:25:29Z
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