Immuno

Leukocyte adhesion deficiency

CD18 - can't tightly bind and get out of blood stream.... no abscess and pus formation.... first sign umbilicus does not fall off
Lymphoid signal

IL-7
Myeloid signal

IL-3
First antibody to be made

IgM
CD 19 and CD 21

B cells
CD 3

T cells
Substances chemoattractive to neutrophils

IL-8 C5a fibriopeptides leukotriene B4 and formyl methionyl peptides
phagocytosis enhanced by

c3b
Chronic granulomatous disease

deficiency of NADPH oxidase - recurrent infection with cat + organisms
inflammatory cytokines

Il-1, Il-6 and TNF-alpha
act as superantigens

staph enterotoxins, TSST-1 and strep pyrogenic exotoxins
Encourage TH1 reaction

IL-12
+ feedback to continue TH1 response

IFN-gamma (which also inhibits TH2 response
Encourage TH2 response

IL-4
+ feedback to continue TH2 response

IL-4 (and inhibits TH1 response)

Author

Anonymous

19025

Card Set

Immuno

Description

from comlex book

Updated

2010-05-12T17:25:29Z