-
Metacholine
- MoA: ACh agonist
- Use: Asthma diagnosis
- Adverse Effect: Short 1/2 life
-
Bethanechol
- MoA: ACh agonist
- Use: relax GI & urinary sm.
-
Carbachol
- MoA: ACh agonist
- Use: relax GI & urinary sm.
-
Pilocaprine
- MoA: muscarinic ACh agonist
- Use: Glaucoma, Xerostomia
-
Cevimeline
- MoA: muscarinic ACh agnoist
- Use: Xerostomia
-
Organophosphorus
- MoA: Irreversible Anti-cholinesterase; bind esteratic site
- Adverse effect: cause muascle paralysis
-
Pralidoxime
- MoA: bind anionic site on cholinesterase; reverse organosphosphorus
- - Give with Atropine
-
Edrophonium
- MoA: short acting Anti-cholinesterase
- Use: DIAGNOSIS of Myasthenia Gravis and NM blockers
-
Neostigmine
- MoA: anti-cholinesterase
- Use: Myasthenia Gravis
- Adverse Effect: cholinergic crisis when OD
-
Physostigmine
- MoA: anti-cholinesterase (CNS action)
- Use: Galucoma, Atropine OD antidote
-
Pyridostigmine
- MoA: anti-cholinesterase
- Use: Myasthenia Gravis, Nerve gas prevention
-
Donepezil
- MoA: anti-cholinesterase
- Use: old Alzheimer's treatments
-
Galantamine
- MoA: anti-cholinesterase
- Use: old Alzheimer's treatments
-
Rivastigmine
- MoA: anti-cholinesterase
- Use: old Alzheimer's treatments
-
Tacrine
- MoA: anti-cholinesterase
- Use: old Alzheimer's treatments
-
Varenicline
- MoA: ACh partial agonist
- Use: competitive inhibitors for ACh over production
-
Atropine
- MoA: Anti-mACh receptors
- Use: systemic parasympathetic inhibitions
-
Scopolamine
- MoA: Anti-ACh receptors
- Use: treat motion sickness
-
Dicyclomine
- MoA: Anti-ACh receptors
- Use: Anti-spasm
-
Ipratropium
- MoA: Anti-ACh receptors
- Use: Bronchodilation (COPD, Asthma)
-
Tiotropium
- MoA: Anti-ACh receptors
- Use: Bronchodilation (COPD, Asthma)
-
Glycopyrrolate
- MoA: Anti-ACh receptors
- Use: inhibits bowl movement (pre-surgical use)
-
Oxybutynin
- MoA: Anti-ACh receptors
- Use: treat overactive bladder
-
Tolterodine
- MoA: Anti-ACh receptors
- Use: treat overactive bladder
-
Darfienacin
- MoA: Anti-ACh receptors
- Use: treat overactive bladder
-
Trihexyphyenidyl
- MoA: Anti-ACh receptors (CNS action)
- Use: Parkinson's treatment
-
Benztropine
- MoA: Anti-ACh receptors (CNS action)
- Use: Parkinson's treatment
-
Tricyclin Anti-depressant
MoA: Anti-ACh receptors
-
Antipsychotic agents
MoA: Anti-ACh receptors
-
H1 Histamine blocking agent
MoA: Anti-ACh receptors
-
Botulinum Toxin A
- MoA: degrades SNAP-25 => prevent ACh release
- Use: chronic migraine
- Adverse effect: flaccid paralysis, respiratory paralysis
-
Botulinum Toxin B
- MoA: degrades VAMP/Synaptobrevin => prevent ACh release
- Use: chronic migraine
- Adverse effect: flaccid paralysis, respiratory paralysis
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