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Methotrexate (antimetabolites)
cancer, RA, psoriasis
MOA: folic acid antagonist
Toxicity- oral and GI ulcerations, myelosuppression, hepatotoxicity
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Anthracyclines (daunorubicin and doxorubacin)
MOA: bind ot DNA, blockas DNA synthesis and cause breaks in DNA- generates free radicals
Toxicity- cardiotoxic
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Alkylating Drugs (Cytoxan)
- Toxicity- myelosuppression, hemorrhagic cystitis (give MESNA to prevent Hemorrhagic cystitis)
- -Nausea/Vomit
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Plant alkaloids (Vincristine)
MOA: binds to tubulin and terminates microtubule (cytoskeleton) assembly - WORKS IN METAPHASE
Toxcitiy: alopecia and neuromuscular deficits
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Plant Alkaloid (vinblastine)
- Toxcitity: leukopenia, neurological
- blasts bone marrow (dose limiting)
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Alkylating drugs (Platinum containing- Cisplatin and Carboplatin)
toxcitiy: severe nausea and vomitting, renal dysfunction, and acoustic nerve dysfunction
most useful alkylating agent= cyclophosphamide
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Antiestrogens
- Use: ER positive breast cancer treatments
- AE: hot flashes, NV
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