-
MOA of Arava
(leflunomide) inhibits Dihydro Orotate Dehydrogenase (DOD)
-
MOA of CellCept
(Mycophenolate) inhibits IMP dehydrogenase -----> inhibits purines ------> inhibits lymphocytes
IMP dehydrogenase converts IMP to GMP
-
MOA of Simponi
(Golimumab) inhibits TNF alpha
-
MOA of Allopurinol
(Zyloprim, Aloprim) inhibit Xanthine Oxidase (XO)
-
Elitek MOA
(Rasburicase) stimulates urate oxidase -----> increases the conversion of Uric acid to Allantoin -----> increases the excretion of Allantoin
-
MOA of Uloric
(febuxostat) decreases the formation of uric acid by inhibiting xanthine oxidase (XO)
-
AE of Imuran, Azasan
- (Azathioprine)
- GI-NVD
- BMD
- hepatotoxic
- stomatitis, pneumonitis, increase infections
-
AE of Neoral
- (cyclosporine)
- 1. increase BP
- 2. gingival hyperplasia (also AE of Dilantin)
- 3. hypertrichosis (also AE of minoxidil (rogaine))
-
AE of Isotretinoin
- (accutane, sotret)
- 1. teratogenic
- 2. muscoskeletal pain
- 3. alopecia
- 4. pseudotumor cerebri; mood swings; Depression
- 5. suicidal ideatioins
- 6. hypothryroidism
-
dosage for Enbrel
(etanercept); SQ 50 q wk
-
Usual dosage for Anakinra
(kineret); SQ 100 mg QD
-
Simponi usual dosing
(Golimumab); SQ q 4wks
-
Arava usual dosage
- (leflunomide);
- initial dose; PO 100 mg for 3 days
- maint. dose; PO 10-20 mg/day
-
Usual dosage of Remicade
- (infliximab);
- RA; IV 3 mg/kg
- PA; IV 5 mg/kg (also for ankylosing spondylitis, Crohns, ulcerative colitis)
-
Indications of Humira
- (Adalimumab)
- 1. RA
- 2. psoriatic arthritis
- 3. ankylosing spondylitis
- 4. ulcerative colitis
- 5. PA
-
Signs and symptoms of Rosecea
- 1. easy blushing, flushing (redness of cheeks)
- 2. telangiectasia (visible blood vessels on cheek, nose)
- 3. Rhinophyma (bulbous, red, congestion)
- 4. Optic (grittiness in eye; vision)
-
-
-
-
allopurinal
zyloprim, aloprim
-
-
-
-
-
plaquenil
hydroxychloroquine
-
-
-
-
-
-
imuran, azasan
azathioprine
-
-
mechlorethamine
mustargen
-
-
-
-
-
-
tacrolimus
prograf, hecoria
-
-
penicillamine
cumprimine, depen
-
-
-
metronidazole
metrogel, metrocream, metrolotion, noritate
-
benzoyl peroxide
benzac, desquem
-
-
tretinoin
retin-A, renova
-
-
isotretinoin
accutane, sotret, amnesteem, claravis
-
-
-
-
-
tazarotene
tazorac, avage
-
Ziana
tretinoin + clindamycin
-
azelaic acid
azelex, finacea
-
sulfacetamide
klaron, sebizon, rosula NS
-
sulfacetamide + sulfur
clenia, rosula, sulfacet-R, Plexion, nicosyn
-
clindamycin
cleocin-T, clindagel, clindamax, evoclin
-
erythromycin
eryderm, erygel, A/T/S
-
-
Benzamycin
benzoyl peroxide + erythromycin base
-
benzaclin
benzoyl peroxide + clindamycin
-
Duac
benzoyl peroxide + clindamycin
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