Med chem quiz 10

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Egrifta

Treat Lipodystrophy in HIV patients
Didanosine/Videx
- NRTI
- Acid labile, dont take with fruit juice
- Peripheral neuropathy, pancreatitis
- Very potent
Lamivudine/Epivir
- NRTI
- Well tolerated
- Drug inter with Bactrim
Stavudine/Zerit
- NRTI
- Dose based on weight
- Contra. with Retrovir
Abacavir/Ziagen
- NRTI
- Very potent but not well tolerated
- Watch for Steven Johnson's
Zalcitabine/Hivid
- NRTI
- Very weak drug
- With or without food
Zibovudine/Retrovir
- First NRTI
- Initial treatment will cause flu-like symp
- Drug interactions that increase bone marrow tox
Emtricitabine/Emtriva
- NRTI New 2003
- Pediatric use
- better absorbed due to a hallogen
Efavirenz/Sustiva
- NNRTI
- Has slower resistance
- Teratogen
- 1/2 pt's will have CNS side effects
Nevirapine/Viramune
- NNRTI
- Effective but can lead to Steven J and fatal hepatitis
Delaviridine/Rescriptor
- NNRTI
- 4 tabs TID (bad pt compl)
- Sulfa allergy
Etravirine/Intelence
- NNRTI
- Do not use with other NNRTI
- Take with ritonavir to help with 3A4 met.
Rilpivirine/Endurant
- NNRTI
- Long 1/2 life
- QT elongation
Tenofovir/Viread
- Nucleotide analog RTI (NARTI)
- Phosphate prodrug
- Take with high fat meal****
- Once daily dose
Saquinavir/Invirase
- Protease inhibitor (PI) First
- Poorly tolerated due to flu
- Can cause arrhythmias
- High Fat meal***
- caution in hemophiliacs
Idinavir/Crixivan
- PI
- Severe diet restrictions (no food)
- Watch for kidney stones
- Must stay in original cont.
Ritonavir/Norvir
- PI (most potent)
- Has worst side effects
- Used for positive drug interactions
Neifinavir/Viracept
- PI
- Not very potent
Amprenavir/Agenerase
- PI
- Sulfa allergy
- Many big Pills
- No Vit E suppl***
Fosamprenavir/Lexiva
- PI
- Prodrug of Amprenaivr
- Increases water solubility
Lopinavir and Ritonavir/Kaletra
- PI
- Combo drug that uses positive drug interaction
Atazanavir/Reyataz
- PI (azapeptide inhibitor)
- Competative inhibitor of natural subst.
- will react with statins due to glucoronidation
Tipranavir/Aptivus
- PI (NON-peptide based)
- The idea was to have less side effects
- Refrigerate
- Must be taken with Ritonavir
Duranavir/Prezista
- PI (NON-peptide based)
- Take with food***
- Take with Ritonavir
- Watch for diabetes
Enfuvirtide/Fuzeon
- HIV entry inhibitor
- Prevents fusion and entry of Viral RNA
Maraviroc/Selzentry
- Chemokine receptor antagonist
- Must have Tropism testing
- 40% of pt will develop mutation and resistance
Raltegravir/Isentress
- INSTI Integrase Strand Transfer Inhibitor
- Blocks integrase enzyme required for insertion of Viral DNA
- Watch for Creatinine Kinase and Rhabdo
Gardasil
- HPV vaccine
- Type 16 and 18 HPV lead to most cervical cancer.
Carvarix

HPV prophylaxis

Author

75ford

187618

Card Set

Med chem quiz 10

Description

Med chem quiz 10

Updated

2012-12-06T23:27:48Z

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