A 51 year-old man has the sudden onset of massive emesis of bright red blood. On physical examination, his temperature is 36.9 degrees C, pulse 103/min, respirations 19/min, and blood pressure 85/50 mm Hg. Laboratory studies show a hematocrit of 21%. The serologic test for HBsAg is positive. He has had no prior episodes of hematemesis. The hematemesis is most likely to be a consequence of which of the following?
B. Esophageal varices
A 45 year-old woman has had increasing pruritus and icterus for several months. On physical examination, she has generalized jaundice. Laboratory studies show total serum protein of 6.3 g/dL, albumin 2.7 g/dL, total bilirubin 5.7 mg/dL, conjugated bilirubin 4.6 mg/dL, AST 77 U/L, ALT 81 U/L, and alkaline phosphatase 221 U/L. A liver biopsy specimen shows destruction of portal tracts and loss of bile ducts as well as lymphocytic infiltrates. Which of the following additional laboratory findings is most likely to be reported?
B. Positive antimitochondrial antibody
A 55 year-old man has developed abdominal pain and jaundice over a period of several weeks. On physical exam, there is right upper quadrant pain but no abdominal distention. An abdominal CT scan shows a markedly thickened gallbladder wall. A cholecystectomy is performed, and sectioning shows a slightly enlarged gallbladder containing a fungating, 4 x 7 cm firm, lobulated tan mass. Which of the following findings is most likely associated with the mass?
Over the past three years, a 65 year-old woman has noticed a slowly enlarging nodule on her face. On physical examination, a 3 cm, nontender, mobile, discrete mass is palpable on the left side of the face, anterior to the ear and just superior to the mandible. The mass is completely excised, and histologic examination shows ductal epithelial cells in a myxoid stroma containing islands of chondroid and bone. This patient is most likely to have which of the following neoplasms?
D. Pleomorphic adenoma
A 60 year-old woman noticed an enlarging "bump" beneath her tongue for the past year. She does not smoke or use alcohol. On physical examination, there is a 2.5 cm movable, submucosal mass arising in the minor salivary glands on the buccal mucosa beneath the tongue on the right. Histological examination of the excised mass shows that it is malignant and locally invasive. The tumor recurs within one year. Which of the following is the most likely diagnosis?
D. Mucoepidermoid carcinoma
A 51 year-old man presents with a slowly progressive jaundice, weight loss, and upper abdominal pain that radiates to his midback. A CT scan shows an irregular mass involving the head of the pancreas. Histologic sections from this mass are most likely to show which of the following?
A 22 year-old woman has had several episodes of aspiration of food associated with difficulty swallowing during the past year. On auscultation, crackles are heard at the base of the right lung. A barium swallow shows marked esophageal dilation above the level of the lower esophageal sphincter. A biopsy specimen from the lower esophagus shows an absence of the myenteric ganglia. Which of the following is the most likely diagnosis?
An 11 month-old previously healthy infant has not produced a stool for one day. The mother notices the the infant's abdomen is distended. On physical examination, the infant's abdomen is very tender and bowel sounds are nearly absent. An abdominal plain film radiograph shows no free air, but there are distended loops of small bowel with air-fluid levels. Which of the following the most likely to produce these findings?
Which one of the following tumor markers is most likely to be used by a clinician who is following a 64 year-old man after surgery for pancreatic adenocarcinoma to look for possible recurrence of the cancer?
D. CA 19-9
A 20 year-old woman in her ninth month of pregnancy has increasing pain on defecation and notices bright red blood on the toilet paper. She has no previous gastrointestinal problems. After she gives birth, the rectal pain subsides, and there is no more bleeding. Which of the following is the most likely cause of these findings?
What mutation is associated with hypertrophic cardiomyopathy? What describes it histologically?
Beta myosin of heavy chains (about 35% of cases)
What is the difference in location of deposition of amyloid and iron with regards to the heart?
Amyloidosis is deposition of amyloid between myocytes
Hemochromatosis is deposition of iron within myocytes
Path test3 mostly quiz6
Path test3 mostly quiz6 - also a few heart questions