Micro Test 3: Parasites of Immunosuppressed

  1. Name 3 species of free living amoeba
    • Naegleria fowleria
    • Acanthamoeba sp.
    • Leptomyxi amebae
  2. Parasites of Immunosuppressed (3)
    • Toxoplasma gondi
    • Pneumocystis (carinii) jirovecci
    • Microsporidia sp.
  3. Free living amoeba type not seen in humans
  4. Free living amoeba type seen in humans
  5. Two stages of Acanthamoeba
    • Cysts- environmentally resistant, diagnostic stage
    • Trophozoites- infective and diagnostic
  6. How do acanthamoeba trophozoites replicate?
  7. What ameba when in inhaled leads to granulomatous emebic enccephalitis (GAE)?
    Acathamoeba (enters CNS via hematogenous spread)
  8. Are acanthamoeba cysts and trophozoites found in tissues?
  9. N. fowferi is found in thermal discharges of power plants
    Like manatees!
  10. 3 Stages in life cycle of N. fowferi
    • Cysts (environmentally resistant)- not in brain tissue
    • Trophozoites (infective and diagnostic)- CSF and tissue
    • Flagellated forms (temporarily non-feeding forms)- CSF
  11. N. fowferi trophozoites infect humans by penetrating the _______ and migrating to the ______ via the _________.  This leads to ____________.
    • nasal mucosa
    • brain
    • olfactory nerve
    • Primary Amebic Meningoencephalitis (PAM)
  12. Type of encephalitis:
    N. fowferi
    • Acanthameoba- Granulomatous amebic encephalitis (GAE)
    • N. fowferi- Primary Amebic Meningoencephalitis (PAM)
  13. An acute suppurative infection of the brain and meninges that is rapidly fatal and usually diagnosed ante-mortum.

    Caused by?
    Primary Amebic Meningoencephalitis (PAM)

    • Caused by Naegleria spp.
    • AmpB (not really effective)
  14. GAE/PAM:  Which one is a more slowly progressive, chronic disease associated with environmental exposures?
    • GAE
    • Acanthamoeba or Leptomyxic amebae
  15. GAE/PAM:  cysts with wrinkled-walls
  16. Ring inflitrate of cornea (yellow eye)
    Acanthamoeba keratitis
  17. Definitive hosts of Toxoplasma gondii
    cats (family Felidae)
  18. What stage of Toxoplasma gondii forms the reservoirs fo infective tissue cysts?
    Non-motile bradyzoite stage
  19. What stage of Toxoplasma gondii exhibits asexual reproduction?
    Motil tachyzoite disease producing stage
  20. + IgM titer in serum of newborn
    Asymptomatic Congenital Toxo (ACT)
  21. Disseminated infection may exist in AIDS pts w/o demonstrable titer
    Serologic Diagnosis of Toxo-1
  22. Fungus causing significant opportunistic infections in immunosuppressed/immunocompromised patients, most common life threatening infection of AIDS patients in US before HAART (Highly Active Anti-Retroviral Therapy)
    Pneumocystic (carinii) jirovecii
  23. Thickened alveolar wwalls and alveoli filled with "foamy" eosinophilic exudate
    Pneumocystis infections
  24. Pneumocystis tx?
  25. Microsporidia develop by _____ to mature spores
    sporongy...is that even a real word?
Card Set
Micro Test 3: Parasites of Immunosuppressed
Parasites of Immunosuppressed