What is the longest safety study of Avamys for pediatric patients?
Maspero 12-week safety study.
Levocetirizine has _______ the affinity for the H1 receptor as compared to Cetirizine which makes it more potent.
twice
Based on the BSACI guidelines, which among the following symptoms of AR is INS the most effective in addressing vs OAH and LTRA- sneezing, nasal itching, nasal congestion?
Nasal congestion
What are the ideal pharmacokinetic profile of an OAH that Levocetirizine has?
Fast onset of action, high & reproducible activity, powerful activity, low intersubject variabillity, long duration of action and safety
How much are Avamys and Nasonex in Mercury (SRP)?
Avamys 120D: P786;
Nasonex: P1,123.75
What are the suggested retail price of all formats of Xyzal in Mercury Drug?
Xyzal Oral Solution PhP261
Xyzal Drops PhP243.25
Xyzal 5mg tablet PhP27
WCP: What is SPIN Selling?
It shows that in successful sales calls it's the buyer who does most of the talking, which means that the salespeople are asking questions.
SPIN Selling proposes that there are 4 types of questions SPIN stands for:
Situation
Problem
Implication
Needs Pay-off
Which type of SPIN question are used to gather general information. They are the easiest questions to ask and answer. They are non-threatening and based on facts.
Situation type
SPIN Qs Examples
How many of your AR cases are mild and how many are moderate to severe?What is the longest duration of time that you prescribed an OAH to your patients
Fluticasone furoate has a systemic bioavailability of _____, has rapid clearance from systemic circulation and >99% plasma protein binding which minimizes systemic exposure to free drug.
0.50%, >99%
In the which study did Levocetirizine exhibit faster wheal inhibition than desloratadine showing superior potency over desloratidine based on receptor occupancy and wheal and flare inhibition?
Gillard 2005 Study
Based on 2008 BSACI (British Society of Allergy & Clinical Immunology) Guidelines, LTRA has no effect on sneezing & nasal itch and OAH has least effect on what AR symptom?
nasal obstruction.
Based on Day 2004 study, what is the onset of action of Desloratadine?
3 hours
In which study were patients 18 yrs old and above with PAR were given FFNS for 52 weeks and showed FFNS does not cause nasal mucosal atrophy with long term daily use?
Fokkens 2012
Which study established Levocetirizine's safety study to as young as 6-month old patients?
Hampel 2010 study
In which study did Levocetirizine has a long-term safety study of 18 months continuous use from 1-2 year old patients
Simons 2007 on behalf of Early Prevention of Asthma in Atopic Children or EPAAC study group
The Allergic Process has 2 phases: the Early phase reaction happens within minutes and Late phase reaction happen in______
6-12 hours.
Can Xyzal be prescribed for pregnant women?
Caution should be exercised when prescribing to pregnant or lactating women as no clinical data is available for use of Xyzal among exposed human pregnancies
What are Implication type of questions?
Implication type of questions in SPIN Selling discuss the effects of the problem, before talking about solutions, and develop the seriousness of the problem to increase the buyer's motivation to change.
What are examples of Implication type of Questions?
Implication Qs Examples: How much of the patients’ poor compliance is related to the unpleasant sensory attributes and device design of the intranasal spray he is using? How much will it cost the patient if his AR will complicate into Asthma ?
Latest IMS data shows that 51% of MDs prefer Avamys vs. other INS brands. For your doctors who are still regular/intermittent users of the brand, don’t forget to ______
DIFFERENTIATE. The AVAMYS ALL WAYS EDA can help you.
What is the OAH prescriptions split for Nasal & Skin as of MAT June 2012 PMDI?
57% Nasal, 43% Skin Rx.
MAT Sem1 2012 data shows that 44% of AR Rx are still OAH monoRx. How do we seize this opportunity?
Seize this opportunity for Avamys by driving early use of the AX combination using your AX eda and allergic process commercial.
Among all OAH prescribers, Dermatologists have the highest per capita, therefore most productive. How much does GPs, IMs, & Pediatricians contribute to the OAH Rx?
83%
Avamys’ fine mist comes in _____ug dose per spray compared to other brands at ____ug dose per spray. Demonstrate how this benefits patients using the FINE MIST VIDEO found in your AX NOW and Avamys All Ways eDAs!
27.5ug
50ug
Pediatricians and GPs contribute about 70% of Nasal and Skin RX for OAH. Pulmonologists yield the highest Nasal RX per doctor, while Dermatologists have the highest RX per doctor for skin indications. In your territory, focus your differentiation efforts to your productive MDs by owning the ______.
Xyzal’s key message of 30 minutes onset of action, providing faster nasal AND skin allergy relief vs other OAH.
Question: According to Berger's study on the Avamys device, what are the benefits of its fine mist formulation?
1) Aids in even nasal distribution,
2) Prevents burning and/or stinging in the nasal cavity,
3) Eliminates aftertaste in the mouth and
4) Sustains the drug in the nasal mucosa for maximum efficacy.
5.) All of the above
1) Aids in even nasal distribution,
2) Prevents burning and/or stinging in the nasal cavity,
3) Eliminates aftertaste in the mouth and
4) Sustains the drug in the nasal mucosa for maximum efficacy.
Xyzal efficacy comes with an established safety profile. In 1 large study, _____% of 17,638 adult patients with respiratory & skin allergies experienced no adverse events. Highlight this to your productive MDs using safety tab in your AX and Skin E-DA!
98.3%
Keith & Scadding's study proved that Avamys is the only INS brand which provides consistent nasal and ocular relief in AR. How many randomized, placebo controlled trials were part of this study?
35
Regular (____ months) long-term treatment with Xyzal effectively prevents and treats urticaria in young children. Highlight this using the Long-term safety page in your AX and Skin E-DA!
18 months
What is the 2012 3 GOs (Growth Opportunities) for Beckman in Avamys Promotion?
Combination Rx, Differentiation, Compliance
What are the 2012 3 GOs (Growth Opportunities) for Beckman in Xyzal Promotion?
Nasal Allergy, Skin Allergy, Pedia Allergy
What is nasal mucosal atrophy?
Pertains to the decrease of the epithelial thickness & size of the turbinates that might result to epistaxis
How long does a chronic urticaria last?
Longer than 6 weeks
How many % patients want an allergy medication that provides long lasting relief
88%
What is our 2012 Strategy for Xyzal?
Differentiate Xyzal as the OAH which provides faster allergy relief vs. other brands
According to a survey done in 2008, what are the factors in deciding on AR prescription?
Side effects, Safe to use, Can be used for children
What are the SEM 2-2012 communication materials which can be used in seizing the skin opportunity in Xyzal?
One of the growth opportunities for Avamys is Combination Rx, What should be highlighted in terms of communication to drive this GO?
Symptom severity, MPI/Allergic Process, Safety
What are the SEM 2-2012 communication materials which can be used in promoting Xyzal for nasal allergies (along with Avamys)?
AX NOW eDA, AX NOW PID material
What dose BSACI stand for?
A. British Society of Asthma and Clinical Immunology
B. British Society of Allergy and Chronic Infections
C. British Society of Allergy and Clinical Immunology
D. British Society of Atrophy and Clinical Immunology
C. British Society of Allergy & Clinical Immunology
When doctor’s objection is focused on the efficacy of Nasonex for nasal
congestion, what studies of Avamys can you best present to address his
concerns?
a. GCR Affinity; Nasal Efficacy
b. Device; Ocular Efficacy
c. None of the above
d. Both a and b
a. GCR Affinity; Nasal Efficacy
Based on the study of Vasar, what is not one of the 4 nasal symptoms
that Avamys is proven to effectively alleviate?
a. Nasal congestion
b. Rhinorrhea
c. Sneezing
d. Eye itch
d. Eye itch
The Nasal efficacy detail aid can be found in which Avamys material?
a. The AX Allergy Mythbusters PID
b. The Omnibus eDA
c. The Avamys INS & Outs eDA
d. Both a and c
a. The Avamys INS & Outs eDA
The GCR Affinity detail aid can be found in which Avamys material?
a. The AX Allergy Mythbusters PID
b. The Omnibus eDA
c. The Avamys INS & Outs eDA
d. All of the above
d. All of the above
Your doctor told you that he trusts Nasonex because it has been in the market for a longer time which means the safety profile of the brand has been proven. Which Avamys material and study can you use to showcase that Avamys is also safe for long-term use?
a. Rosenblut-One year study
b. Rosenblut-Two year study
c. Maspero- Six months study
d. Maspero- One year study
a. Rosenblut-One year study
The longest safety detail aid of Avamys can be found in which Avamys
material?
a. The Omnibus AX eDA: Adult Version (GP/IM)
b. The Omnibus AX eDA: Pedia Version
c. The Avamys INS & Outs eDA
d. A and C only
a. The Avamys INS & Outs eDA
What is the systemic absorption rate of Avamys?
a. Less than 1%
b. A little higher than 1%
c. Exactly 1%
d. Significantly above 1%
a. Less than 1%
Your doctor’s objection is focused on the fast onset of action of Omnaris. What is a good way of handling this based on the concept of inflammation?
a. There is a marginal short-term patient benefit of fast onset of action, but once you have the inflammation under control the onset of action becomes irrelevant.
b. Immediate onset of action plays a more significant concern in AR
management than controlling inflammation.
c. Inflammation control cannot be achieved if onset of action is not immediate.
d. None of the above
a. There is a marginal short-term patient benefit of fast onset of action, but once you have the inflammation under control the onset of action becomes irrelevant.
Fill in the blank. Based on Kaiser’s study, Omnaris’ onset of action is observed to be inconsistent across studies:
within _______ .
a. 3-4hrs
b. 6-48hrs
c. 6-24hrs
d. 1-3hrs
b. 6-48hrs
Looking at your OAH and INS portfolio, what will you recommend to your
doctor who is concerned with immediate symptom-relief for his AR patients?
a. Xyzal
b. Avamys
c. FANS
d. Combined Avamys & FANS
a. Xyzal
You want to discuss the onset of action of the different INS brands with your doctor. Which Avamys material contains this information?
a. The AX Allergy Mythbusters PID
b. The Avamys INS & Outs eDA
c. The Omnibus AX eDA
d. Both B and C
b. The Avamys INS & Outs eDA
Your doctor’s objection is focused on Omnaris’ high tissue
retention. In your Avamys INS & Outs eDA- tissue retention tab, for as long as how many hours is Avamys observed to stay?
a. Up to 24 hours
b. Up to 30 hours
c. Up to 12 hours
d. Up to 6 hours
b. Up to 30 hours
Your doctor’s objection is focused on Omnaris being gentle on the nose. What can you talk about to counter
your doctor’s arguments?
a. Fine Mist and Safety Profile
b. GCR Affinity and High Tissue Retentoin
c. Onset of Action and Fine Mist
d. None of the above
a. Fine Mist and Safety Profile
You want to compare the volume per spray released using the Avamys device vs the other INS brands. Which of the following Avamys materials can you
use to detail on this?
a. The AX Allergy Mythbusters PID
b. The Avamys INS & Outs eDA
c. The Omnibus AX eDA
d. Both B and C
b. The Avamys INS & Outs eDA
To further build on the advantages of Avamys, you want to talk about our brand’s efficacy in addressing ocular symptoms in addition to nasal. Which of the following Avamys materials would contain Keith and Scadding’s study
comparing the efficacy of the different INS brands in addressing ocular symptoms of AR?
a. The AX Allergy Mythbusters PID
b. The Avamys INS & Outs eDA
c. The Omnibus AX eDA
d. Both B and C
b. The Avamys INS & Outs eDA
When a Pedia MD is a high Cetirizine user due to its favorable safety profile, Which e –detailer material is best to use?
a. Safety: Pampura 2011
b. Optimal AR management
c. Efficacy: 30 minutes faster relief
d. A and C
a. Safety: Pampura 2011
What is the conclusion of Devalia 2001 Study?
a. Levocetirizine has a higher wheal inhibition compared to Desloratadine
b. Levocetirizine has a lower pruritis score compared to Cetirizine
c. Levocetirizine has a higher wheal inhibition compared to Cetirizine
d. Levocetirizine has a lower pruritus score compared to Desloratadine
c. Levocetirizine has a higher wheal inhibition compared to Cetirizine
Based on the survey done by the Asthma and Allergy Foundation of America (2005), what is the percentages of allergy patients that want a quick-relief and quick allergy symptom?
a. 85%, 83%
b. 50%, 70%
c. 70%, 50%
d. 85%, 80%
a. 85%, 83%
What is the duration of the long term safety study of Levocetirizine?
a. 12 months
b. 18 months
c. 24 months
d. 6 months
b. 18 months
According to the American Journal of Medicine (2002): Comparative Pharmacology of H1 Antihistamines, what is the onset of action of Loratadine?
a. 3-4 hrs
b. 1-2 hrs
c. 2-3 hrs
d. 1hr
a. 3-4 hrs
What is the conclusion of the Anuradha 2010 Study?
a. Levocetirizine has improved the symptoms of pruritus, size of wheals, and number of urticarial episodes in patients better than Cetirizine
b. Levocetirizine has improved the symptoms of pruritus, size of wheals,and number of urticarial episodes in patients better than Loratadine
c. Levocetirizine has improved the symptoms of pruritus, size of wheals,and number of urticarial episodes in patients better than Cetirizine, Loratadine and Desloratadine
d. Levocetirizine has improved the symptoms of pruritus, size of wheals, and number of urticarial episodes in patients better than Desloratadine
b. Levocetirizine has improved the symptoms of pruritus, size of wheals, and number of urticarial episodes in patients better than Loratadine
What study that can be discussed to an MD who is a heavy Lorano user when treating urticaria?
a. Pampura 2011
b. Devalia 2001
c. Potter 2008
d. Anuradha 2010
d. Anuradha 2010
What is the conclusion of the Potter 2008 study?
a. Levocetirizine led to a greater decrease in pruritus severity than Desloratadine for the entire 4-week treatment period in symptomatic CIU patients.
b. Levocetirizine led to a greater decrease in pruritus severity than Desloratadine for the entire 2-week treatment period in symptomatic CIU patients.
c. Levocetirizine led to a greater decrease in nasal symptom score than Desloratadine for the entire 4-week treatment period in SAR patients.
d. Levocetirizine led to a greater decrease in nasal symptom score than Desloratadine for the entire 4-week treatment period in SAR patients.
a. Levocetirizine led to a greater decrease in pruritus severity than Desloratadine for the entire 4-week treatment period in symptomatic CIU patients.
What feature of Levocetirizine that was highlighted in Simmons 2002 study?
a. Fast onset of action
b. Long term safety
c. Wheal & flare inhibition
d. Fast onset of action & Long term safety
a. Fast onset of action
What clinical studies can be discussed to an MD who prefers Cetirizine in treating urticaria because of its fast-acting and good safety profile?
a. Devalia 2001, Anuradha 2010
b. Anuradha 2010, Simmons 2002
c. Simmons 2002, Devalia 2001
d. Simmons 2002, Potter 2008
c. Simmons 2002, Devalia 2001
What is the pharmaceutical company promoting Aerius and Claritin?
a. UAP
b. MSD
c. OEP
d. Cathay
b. MSD
What is the pharmaceutical company promoting Lorano?
a. UAP
b. Westmont
c. Sandoz
d. Ajanta
c. Sandoz
What is the generic name of Allerkid and Alnix
a. Loratadine
b. Desloratadine
c. Hydroxyzine
d. Cetirizine
d. Cetirizine
Levocetirizine is __ times the affinity Cetirizine.
a. Three
b. Two
c. Four
d. Twenty
b. Two
What is the WHEN, WHY, HOW of Xyzal?
a. For nasal and skin allergy patients, Xyzal provides a potent and faster allergy relief vs other Antihistamines, 5 mg tablet once daily for adult and 2.5 ml BID oral solution for 2-6 years old
b. For nasal and skin allergy patients, Xyzal provides a faster allergy relief vs other Antihistamines, 5 mg tablet once daily for adult and 2.5 ml BID oral solution for 2-6 years old
c. For nasal and skin allergy patients, Xyzal provides a faster allergy relief in 30 minutes, 5 mg tablet once
daily for adult and 2.5 ml BID oral solution
for 2-6 years old
d. For nasal and skin allergy patients, Xyzal provides a faster allergy relief vs other Antihistamines, 5 mg tablet once daily for adult and 2.5 ml OD oral solution for 2-6 years old
b. For nasal and skin allergy patients, Xyzal provides a faster
allergy relief vs other Antihistamines, 5 mg tablet once daily for adult and 2.5 ml BID oral solution for 2-6 years old
What is BSACI’s stand on the combination of OAH + LTRA in the management of allergic
rhinitis?
a. The combination of OAH & LTRA is no more effective than INS alone
b. The combination of OAH & LTRA is more effective than INS alone
c. The combination of OAH & LTRA is equally effective as INS monotherapy
d. None of the above
a. The combination of OAH & LTRA is no more effective than INS alone
When does the early phase of the Allergic Process happen?
A. Within minutes
B. Within 2-4 hours
C. Within 6-12 hours
D. Within 24-48 hours
A. Within minutes
When does the late phase of the Allergic Process happen?
A. Within minutes
B. Within 2-4 hours
C. Within 6-12 hours
D. Within 24-48 hours
C. Within 6-12 hours
Which symptoms are elicited by the release of inflammatory mediators which happens in Early Phase of Allergic Process?
A. Sneezing
B. Congestion
C. Rhinorrhea
D. All of the above
D. All of the above
What is nasal mucosal atrophy?
A. Pertains to the decrease of the epithelial thickness & size of the turbinates that might result to epistaxis
B. Pertains to the decrease of mucosal secretion that might result to epistaxis
C. Pertains to the increase of mucosal secretion that might result to epistaxis
D. None of the above
A. Pertains to the decrease of the epithelial thickness & size of the turbinates that might result to epistaxis
What is the conclusion of Fokken’s study “No Mucosal Atrophy And Reduced Inflammatory Cells: Active Controlled Trial with year long Fluticasone Furoate Nasal Spray” on FF and mucosal atrophy?
A. FFNS does not cause atrophy or detrimental changes in nasal mucosa with short-term use
B. FFNS does not cause atrophy or other detrimental changes in the nasal mucosa with long-term daily use
C. FFNS causes minor atrophy and changes in the nasal mucosa with long-term use
D. FFNS causes major atrophy and changes in the nasal mucosa with long-term use
B. FFNS does not cause atrophy or other detrimental changes in the nasal mucosa with long-term daily use
Among FFNS patients used in Fokkens’ study, was there mucosal crusting observed?
A. Yes to 85% of subjects
B. No to 85% of subjects
C. Yes to 55% of subjects
D. No to 55% of subjects
B. No to 85% of subjects
What is the profile of patients used for Fokken’s study on No Mucosal Atrophy And Reduced Inflammatory
Cells: Active Controlled Trial with year long Fluticasone Furoate Nasal Spray?
A. 18 years old & above with PAR
B. 6 years old & above with PAR
C. 2 years old & above with PAR
D. 18 years old & above with PAR/SAR
A. 18 years old & above with PAR
How long were the patients in Fokkens Study subjected to use of FFNS?
A. 12 weeks
B. 24 weeks
C. 52 weeks
D. 100 weeks
C. 52 weeks
What inflammatory cell is considered as important indicator of an allergic basis of rhinitis?
A. Mast cell
B. Eosinophil
C. Neutrophil
D. Lymphocyte
B. Eosinophil
Fill in the blank: The decrease of epithelial thickness brought by atrophy increases sensitivity of the nasal mucosa that might result to__________.
A. Crusting
B. Increased allergic reaction
C. Nasal congestion
D. Epistaxis
D. Epistaxis
What is a kind of skin rash notable for dark red, raised, itchy bumps and also known as hives?
A. wheal
B. Urticaria
C. Flare
D. Insect bites
B. Urticaria
How long does a chronic urticaria last?
A. Longer than 1 week
B. Longer than 2 weeks
C. Longer than 4 weeks
D. Longer than 6 weeks
D. Longer than 6 weeks
Most patients with chronic urticaria are idiopathic. What does idiopathic mean?
A. Unknown
B. Contagious
C. non-curable
D. severe
A. Unknown
What is the BSACI recommended initial treatment plan for Chronic Urticaria?
A. Standard dose of sedating H1 antihistamine
B. Standard dose of non-sedating H1 antihistamine
C. Standard dose of non sedating H1 antihistamine plus LTRA
D. Standard dose of oral steroid
B. Standard dose of non-sedating H1 antihistamine
True or False: Levocetirizine has a study on 6-month old patients
A. True
B. False
A. True
What is the duration of the long-term safety study for Levocetirizine?
A. 4 months
B. 8 months
C. 12 months
D. 18 months
D. 18 months
What is the age of subjects in the study published in 2007
authored by F. Estelle R. Simons for the Early Prevention of Asthma in Atopic Children Study Group ?
A. 6 months to 5 years
B. 12-24 months
C. 2-6 years
D. None of the above
B. 12-24 months
In Pampura 2011 study wherein Cetirizine’s ETAC study and Levocetirizine’s EPAAC study was compared, which
neurological/behavioural events reported less frequent with Levocetirizine compared to Cetirizine?
A. Somnolence
B. Nervousness
C. Insomnia and fatigue
D. All of the above
D. All of the above
What does EPAAC stand for?
A. Early Prevention of Asthma in Atopic Children
B. Early Prevention of Allergy in Asthmatic Children
C. Early Prevention of Asthma in Allergic Children
D. Early Prevention of Asthma in Atopic Chances
A. Early Prevention of Asthma in Atopic Children
What is the stand of ARIA & GINA on the use of montelukast on allergic rhinitis or asthma?
a. Leukotrienes are the best treatment options for either AR or asthma
b. Leukotrienes are alternative treatments only for either AR or asthma
c. Leukotrienes are the best treatments options for children
with either AR or asthma
d. Leukotrienes are the best treatments options for children and adult with either AR or asthma
b. Leukotrienes are alternative treatments only for either AR or asthma
According to BSACI, LTRA plus OAH combinations do not improve efficacy to a clinically relevant extent compared with either drug used alone. True or False?
a. True
b. False
a. True
Among the 5 symptoms of allergic rhinitis, for which is INS more effective than OAH and LTRA according to BSACI?
a. Sneezing
b. Rhinorrhea
c. Nasal obstruction
d. Eye Symptoms
c. Nasal obstruction
True or False. Treatment of AR decreases
the risk of developing associated disease like ASTHMA (significantly lower risk of hospitalizations or attending accident & ER visits)
a. True
b. False
a. True
Compare the absolute bioavailability of Avamys & a montelukast brand (Montemax).
a. Avamys: 0.50%, Montelukast: 0.05%
b. Avamys: 0.50%, Montelukast: 5%
c. Avamys: 0.50%, Montelukast: 64%
d. Avamys: 0.50%, Montelukast: 6.4%
c. Avamys: 0.50%, Montelukast: 64%
The cost of Avamys per spray is P13.1. How much is the cost of one Montelukast 4mg chewable tablet?
a. P18.75
b. P27.75
c. P25.75
d. P12.75
a. P18.75
Is Zykast indicated for use for 2yo children?
a. Yes
b. No
b. No
BSACI Guideline shows a table of the effect of therapies on rhinitis symptoms. Comparing OAH, INS and LTRA, OAH is shown to have the highest (+++) effect on which of the following rhinitis symptoms?
a. Sneezing
b. Rhinorrhea
c. Nasal Itch
d. Nasal Obstruction
c. Nasal Itch
Based on BSACI Guideline, LTRA has no effect on which of the following Rhinitis Symptoms?
a. Sneezing and Rhinorrhea
b. Sneezing and Nasal Obstruction
c. Sneezing and Eye Symptoms
d. Sneezing and Nasal Itch
a. Sneezing and Nasal Itch
According to ARIA, Anti-leukotriene is not recommended given its limited efficacy. True or False?
a. True
b. False
a. True
ARIA proposes a step-wise medical treatment for Allergic Rhinitis. What is the drug of choice for mild, intermittent AR, based on ARIA?
a. OAH
b. LTRA
c. INS
d. All of the above
a. OAH
You have been communicating to your MDs about Avamys and Xyzal as the preferred treatment for Allergic Rhinits. What other key message can you communicate to your MD who has started using FDC Montelukast and Levocetirizine for his patients?
a. Aside from efficacy, both Avamys and Xyzal
have established safety for both pediatric and adult patients
b. Limited scientific data is available for Fixed
dose combination to establish safety.
c. Safety data available were studies on FDC’s
individual components
d. All of the above
d. All of the above
Zykast and Co-Altria are indicated for patients at what age?
a. Zykast and Co-Altria only for patients 12 years
old and above
b. Zykast and Co-Altria for patients 2 years old and above
c. Zykast for patients 12 years old and above, Co-Altria for patients 2 years old and above
d. Zykast for patients 2 years old and above, Co-Altria for patients 12 years old and above
c. Zykast for patients 12 years old and above, Co-Altria for patients 2 years old and above
Zykast and Co-Altria are not available in drops or oral solution formats. True or False?
a. True
b. False
a. True
How much is the suggested retail price of Xyzal tablet?
A. 22
B. 24
C. 26
D. 27
27
How much is the suggested retail price of Xyzal Oral Solution?
B. 261
How much is the suggested retail price of Xyzal Oral Drops?
C. 243.25
How much is the suggested retail price for Avamys 120D?
C. 786
How much is the suggested retail price for Nasonex?
D. 1123.75
Based on the MAT sem1 2012 data, how many percent are still monotherapy users for AR Rx?
44%
Reflective Total Ocular Symptom score (rTOSS) is the measure of efficacy against ocular symptoms of AR throughout _________ (every _____ hours) while Instantaneous Total Ocular Symptom Score (iTOSS) is the measure of efficacy against ocular symptoms ____________.
day and night
12
after the last dose
What is the proper handling and storage of Xyzal oral drops and solution?
For unopened, oral drops & solution last for 2 years and last for 3 months when opened. It should be kept at 30°C
TNSS is a common primary endpoint in some efficacy studies of Avamys. What does TNSS (Total Nasal Symptom Score) mean?
It is composed of the sum of individual nasal symptom scores for nasal congestion, rhinorrhea, nasal itching and sneezing. The total sum of scores is equivalent to 12
Levocetirizine has a dissociation half-time more than __ higher than dextrocetirizine
20
What is the longest safety study of Avamys for adolescents and adults?
Rosenblut’s 1-year safety study
Xyzal 5mg tablets should be stored at what temperature?
Below 25°C
What are Need-Pay off type of SPIN questions?
Need-Pay off type of questions in SPIN Selling are the solution because the conversation can be moved from the pain of the problem to the gain or pleasure the buyer wants from the solution. What these questions do is probe for explicit needs.
What are examples of Need-Pay off questions?
How would it help your patient if an intranasal corticosteroid spray has a patient-friendly device and pleasant sensory attributes ?How can a drug with consistent efficacy for both ocular and nasal symptoms help your Allergic Rhinitis patients? --How about you, what other examples of Need Pay-off type of questions can you think of?
Which study done for Avamys that focuses on the result: FFNS has no adverse effect on HPA axis function in 2-11 years old pediatric patients with PAR?
Tripathy’s 6-week study on HPA axis suppression
What is the general pediatric dosage of Xyzal?
0.125 mg/kg/dose
You’ve just told Doctor A that the BKC content of Avamys is at 0.015%. His question is, What is the allowable BKC content based on the American College of Toxicology?
0.10%
Who is the main author of the study showing Levocetirizine caused greater wheal inhibition of 40.2% at 32h after dosage, compared with 24.3% inhibition caused by Cetirizine?
Devalia (2001)
Based on studies, how many of asthmatic patients have allergic rhinitis?
80%
The dosing of Avamys is 2 sprays per nostril once a day. Based on PI, what is the dosing of Nasonex for adults?
2 sprays per nostril twice a day
Based on CPI, what are the “common” adverse events of Xyzal?
Headache, Somnolence, Dry mouth
What are the primary symptoms of AR?
Primary symptoms are Repetitive sneezing, rhinorrhea, nasal itch, post nasal drip, nasal congestion, ocular.
What are the secondary symptoms of AR?
Secondary symptoms are sorethroat, chronic cough, sinus headaches, daytime fatigue.
In a study conducted in EPAAC, as cited in ________ paper, overall neurologic/behavioural events were less frequently reported with levocetirizine (6.3% of the children) than with CETIRIZINE (16.3% of the children), with large differences noted in the incidence of somnolence, irritability/nervousness, insomnia and fatigue.
Pampura 2011
Which SPIN selling type of questions ask about the customers' difficulties or dissatisfaction and focus the customer on while clarifying the problem.
Problem type
Problem Qs Examples
How easy is it to use the intranasal device your AR patient is currently using? What happens when your moderate to severe AR patients are on oral antihistamine only?
