Med Chem Virus

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Foscarnet/Foscavir
- Anti-herpes (Phosphate)
- Very toxic to kidneys
- Inhibiits DNA rep.
Acyclovir/Zovirax
- Synthetic nucleoside
- triphosphate inhibits DNA
- Class B pregnancy
Valacyclovir/Valtrex
- Prodrug of acyclovir
- Oral only
Ganciclovir/Cytovene
- Synthetic nucleoside
- used for cytomeg. in pt with immuno comp.
- Very toxic
Valgaciclovir/Valcyte
- Synthetic nucleoside
- CMV in immuno comp and transplant pt. (not liver trans)
- Plasma levels similar to IV Ganciclovir
Penciclovir/Denavir

Topical Cream
Famciclovir/Famvir

Prodrug oral form of Penciclovir
Cidofovir/Vistide
- For pt that failed with ganciclovir
- Injection only, must be administered with probenecid
Abreva
- Cream for oral and facial herpes
- MOA inhibits viral replication
Vitravene
- Removed from the market
- Anti-sense technology
- Injected into the eyeball
Idoxuridine/Dendrid

MOA resembles thymidine, incorperates into DNA making pseudostructures.
Trifluridine/Viroptic

Opthalmic, keratoconjunctavitis
Vidarabine/Vira-A
- Topical Opthalmic
- Discontinued in US
Ribavirin
- Anti RSV agent
- Only in ICU
- Only for kids
Synagis
- Anti RSV
- IM injection
- Safety and efficacy not established
Ribavirin+interferon/Copegus

Used to treat Hepatitis
Adefovir/Hepsera
- Hep B
- Adenosine analog (prodrug)
- Prevents DNA polymerase
Telbivudine/Tyzeka
- Thymidine analog
- Chronic Hep B 16yrs old+
- No activity against HIV
- Lactic acidosis
Entecavir/Baraclude
- guanosine analog (Hep B)
- Very Potent
Telaprevir/Incivek
- Hep C
- Diet is very important (New 2011)
- Take with 20g of fat
Boceprevir/Victrelis
- Hep C
- Take with food
Amantadine/Symmetrel
- Anti-Influenza
- Treat Parkinsons from CO poisining
Ramantadine/Flumadine

Anti-Flu
Oseltamivir/Tamiflu
- Anti-Flu neuraminidase inhibitor
- Drug of choice for avian flu
- Can lead to mental instability
Zanamivir/Relenza
- Anti-flu
- Inhaled powder
- Do not use in pt with pulmonary disease

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75ford

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Med Chem Virus

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Med Chem Virus

Updated

2012-11-28T03:17:31Z

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