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NCTI- Pharmacology- Drug List C- Dopamine
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Dopamine
trade name
Intropin
Dopamine
class
Sympathomimetic
Catecholamine
Vasopressor
Dopamine
mechanism of action
Low Dose or Renal/Mesenteric Dose (1-5 mcg/kg/min):
Dilates renal and mesenteric arteries by stimulating dopaminergic receptors
May decrease blood pressure due to vasodilation
Increases urinary output
Moderate Dose or Inotropic Dose (5-10 mcg/kg/min):
Increases inotropy without increasing chronotropy
Increases blood pressure by stimulating the beta1 receptors
High Dose or Vasopressor Dose (10-20 mcg/kg/min):
Causes vasoconstriction
Increase inotropy and chronotropy
Increases blood pressure by stimulating the alpha and beta1 receptors
Dopamine
indications
Cardiogenic shock
Distributive shock after fluids
Hemodynamically significant hypotension
Symptomatic bradycardia (second line drug)
Dopamine
contraindications
Hypovolemia
Tachydysrhythmias
Dopamine
side effects
Cardiovascular
: tachycardia, hypertension/hypotension, chest pain, ventricular irritability
Respiratory
: dyspnea
Dopamine
precautions
Cannulate largest vein possible and ensure IV patency (necrotic)
Start a second IV line if additional medications are needed (Dopamine infusion should not be interrupted to ensure adequate therapeutic blood levels)
Dopamine
interactions
Flush tubing before and after administration of Sodium Bicarbonate as Dopamine will be inactivated by the change in pH
Actions may be intensified if patient is also taking antidepressants
May cause hypotension if patient taking phenytoin (Dilantinīĸ)
Dopamine
routes
IVPB
Dopamine
onset and duration
Onset in 5 minutes and will last 3-5 minutes
Dopamine
dosages
Adult
: Add 400 mg into 250 ml Normal Saline solution (creating1600 mcg/ml solution)
Low dose
: 1-5 mcg/kg/min
Moderate dose
: 5-10 mcg/kg/min
High dose
: 10-20 mcg/kg/min
Pediatric
: Add 400 mg into 250 ml Normal Saline solution (creating1600 mcg/ml solution)
Low dose
: 1-5 mcg/kg/min
Moderate dose
: 5-10 mcg/kg/min
High dose
: 10-20 mcg/kg/min
Dopamine
notes
Flow rate determines which receptor sites are stimulated and results in a graded response
Frequent vital signs are required for all patients with a Dopamine infusion
Once appropriate blood pressure is achieved, infusion may need to be slowed but should not be stopped
Author
RunNickMarini
ID
18557
Card Set
NCTI- Pharmacology- Drug List C- Dopamine
Description
NCTI- Pharmacology- Drug List C- Dopamine
Updated
2010-05-10T03:31:08Z
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