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The ability to cause disease
pathogenicity
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the extent of pathogenicity
virulence
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mucous membranes, skin,parenteral route, and preferred portal are all example of
portals of entry
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infectious dose for 50% of the test population is
ID50
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Lethal dose (of toxin) for 50% of the test population is
LD50
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These three things Glycocalyx, fimbriae and m protein help an organism to do what?
Adherence or attach to the host so they are infecious and also form biofilms
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Thi sprotein helps sticks or adheres and also resist phagocytotosis
M protein, this is a cell wall component
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This protein inhibits T helper cells
Opa protein, this is a cell wall component
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This is a waxy lipid that resists digestion
mycolic acid, this is a cell wall component
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Coagulates fibrinogen
coagulase
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Digest fibrin clots
Kinases (fibrinolysin)
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Hydrolyzes hyaluronic acid
hyaluronidase
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hydrolyzes collagen
collagenase
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destroys igA antibodies
igA proteases
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This is where a bacteria alters the hosts actin (skeleton of cell wall) to enter a host cell
invasion
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these use ________ to move from one cell to the next
actin
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Substance that contributes to pathogenicity?
Toxin
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The ability to produce a toxin
toxigenicity
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The presence of toxin in the host's blood
toxemia
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The inactivated toxin used in a vaccine
toxoid
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Antibodies against a specific toxin is called?
Antitoxin
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Neurotoxin, enterotoxin and cytotoxins are examples of what?
toxins...just effect different parts of the body
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exotoxins are secreted where?
outside the cell, they exit out
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gram + form what kind of toxins?
exotoxins
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explain what the a-b exotoxin B stand for?
B is for binding wher eit attaches to the hosts receptor
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What does the A do in a-b exotoxins?
It alters cell functio by inhibiting protein synthesis
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Some exotoxins do not enter the host cell but go in through poking holes by making protein channels in the plasma
membrane-disrupting exotoxins
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Very potent exotoxins are called?
Superantigens
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These cause an intense immune response due to release of cytokines from host cells and symptoms include fever, nausea,vomiting diarrhea shock and death
superantigens
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The exotoxin in corynebacterium diphtheriae is?
A-B toxin
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The toxin in Streptococcus pyogenes is?
Membrane-disrupting erythrogenic toxin
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The toxin in closttridium botulinum is
A-B toxin: neurotoxin
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The toxin in C. tetani is?
A-B toxin: neurotoxin
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The toxin in Vibrio chloerae is?
A-B toxin: enterotoxin
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What toxin is in Staphlococcus aureus?
Superantigen
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Toxic shock syndrome is due to what antigen>?
superantigen
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Endotoxin are part of what of the cell?
The cell wall in gram neg
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The only organisms that can have endotoxins are?
gram neg
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Lipid A is?
a toxin released from a gram neg organism
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In gram neg endotoxins release large amounts when a cell????? and small amts when a cell????
dies,:::divides
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