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Midazolam
trade name
Versed
-
Midazolam
class
- Amnesic Agent
- Sedative/hypnotic
- Anticonvulsant
- Benzodiazepine
- Tranquilizer
- Anti-anxiety (anxiolytic)
-
Midazolam
mechanism of action
- Reduces anxiety
- Relaxes skeletal muscles
- Produces short term CNS depression and amnesia
-
Midazolam
indications
- Seizures
- Premedication for synchronized cardioversion/TCP
- One of the premeditations for RSI
-
Midazolam
contraindications
- Acute narrow-angle glaucoma
- Shock (from hypovolemia)
- Hypotension (from hypovolemia)
- Alcohol or drug intoxication
- Allergies to cherries
-
Midazolam
side effects
- Cardiovascular: bradycardia, rebound tachycardia, hypotension
- Neurological: amnesia, drowsiness, agitation, ALOC
- Respiratory: respiratory depression or arrestG
- astrointestinal: nausea/vomiting
-
Midazolam
precautions
- Elderly patients with impaired respiratory function
- Patients with renal failure, liver failure or COPD
-
Midazolam
interactions
Other CNS depressants or benzodiazepines
-
Midazolam
routes
IV, IO, IM, IN
-
Midazolam
onset and duration
Onset in 1-5 minutes (IV/IO/IN) or 5-15 (IM) and may last 2-6 hours
-
Midazolam
dosages
- Adult:
- Pre-cardioversion or transcutaneous pacing: – 2.5 mg slow IV/IO
- Seizure: 0.1 mg/kg slow IV/IO/IN or 0.2 mg/kg IM to a maximum of 5.0 mg
Pediatric: Seizure: 0.1 mg/kg slow IV/IO/IN or 0.2 mg/kg IM to a maximum of 5.0 mg
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