MDD

late 20s but can occur at any age

• peak onset :
• females: 35-45
• males: 55 or older

10.3%

• female gender
• postpartum
• unstable marriage
• prior episodes/suicide
• lack of social support

• YES!!
• 50-60% after first episode
• 70% after second episode
• 90% after third episode

all ssri's BUT fluvoxamine

good choice for non-compliant pts due to its long half-life. can be useful in pts complaining of fatigue, sedation, or decreased energy

fewer drug intxns but requires a dose of 200 mg/day. easier to titrate in geriatrics and patients with anxiety

lease activating and may be better for patients having difficulty sleeping

has reported to produce less sexual dysfunction than other SSRI's (but claim remains unclear!!!)

considered to be no better than citalopram

seizure disorder, bulimia or anorexia