NCTI- Pharmacology- Drug List A- Morphine Sulfate

none

• opioid narcotic
• CNS depressant

• 1. Alters pain perception and produces euphoria
• 2. Decreases myocardial oxygen demand by decreasing preload (venous pooling due to peripheral vasodilation) and decreasing afterload (decreased systemic vascular resistance due to peripheral vasodilation)
• 3. Depresses the CNS by interacting with opiate receptors in the brain

• Moderate to severe pain
• Chest pain of suspected myocardial origin
• Pulmonary Edema from Congestive Heart Failure with or without chest pain
• Burns

• Altered level of consciousness
• Abdominal pain of unknown etiology
• Respiratory depression
• Head injury
• Hypovolemia

• Cardiovascular: bradycardia, hypotension, (rebound tachycardia/hypertension)
• Neurological: sedation, agitation, tremors/seizures, hallucinations
• Respiratory: depression, arrest
• Gastrointestinal: nausea/vomiting

Morphine Sulfate is an opiate derivative – Naloxone should be available to reverse any severe respiratory side effects

Use with caution with patients taking other analgesics, depressants or narcotics

IV, IO, IM

IV/IO will have an onset of 2-5 minutes and IM will have an onset of 5-10 minutes. Each will last approximately 3-5 hours

• Adult:
• Pain Relief: 1.0 – 10.0 mg IV titrated to pain relief or 5.0 – 10.0 mg IM as a single dose only
• Pulmonary Edema: 5.0 – 10.0 mg slow IV push (2.0 mg/minute)

Pediatric: 0.1 – 0.2 mg/kg slow IV push (1.0 mg/minute) titrated to pain relief or 0.1 mg/kg IM

May draw 10 mg (1 ml) into a 10 ml syringe and mix with 9 ml of Normal Saline. This creates a 1 mg/1 ml concentration for better control when administering the medication.