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Acetylsalicylic Acid
trade name
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Acetylsalicylic Acid
class
- Analgesic
- Antipyretic
- Platelet Aggregate Inhibitor
- NSAID
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Acetylsalicylic Acid
mechanism of action
- 1. Inhibits aggregation (clumping) of platelets by blocking the formation of the substance thromboxane (A2) ; prolonging bleeding time
- 2. Provides analgesia by inhibiting prostaglandins and other substances that sensitize pain receptors (blocking of prostaglandins also accounts for the drug’s anti-inflammatory effects).
- 3. Relieves fever by acting upon the hypothalamic heat regulating center
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Acetylsalicylic Acid
indications
- 1. Acute myocardial infarction
- 2. Thrombotic stroke
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Acetylsalicylic Acid
contraindications
- 1. Active gastrointestinal bleeding
- 2. Asthma patients with nasal polyps (anaphylaxis is common)
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Acetylsalicylic Acid
side effects
- Gastrointestinal: bleeding, heartburn, epigastric pain
- CNS: dizziness, confusion, drowsiness
- ENT: tinnitus, hearing loss
- Other: may impair renal function, may prolong labor in pregnancy with increased bleeding
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Acetylsalicylic Acid
precautions
- 1. Medical history of pre-existing ulcers, liver disease or bleeding disorders
- 2. Due to the possible association of aspirin with Reye’s syndrome, do not give drug to children or teenagers with signs and symptoms of chickenpox (varicella) without physician consultation
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Acetylsalicylic Acid
interactions
- 1. inhibits anti-hypertensive effects of ACE inhibitors
- 2. Ammonium chloride and other urine acidifying drugs will increase effects of aspirin – watch for toxicity
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Acetylsalicylic Acid
routes
PO
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Acetylsalicylic Acid
onset and duration
Onset is 5-30 minutes and may last 1-4 hours, peak in 15 min.
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Acetylsalicylic Acid
dosages
- Adult: 162-325 mg PO
- Pediatric: not recommended
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Acetylsalicylic Acid
notes
none
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