STATINS - DR. DAVIS

True or false. The higher the risk, the lower the LDL target level.
True False

Which of the following describes the mechanism of action for cholestyramine and colestipol?

A. activates GPCR in adipose and decreases the release of fatty acids from stored triglycerides
B. activates PPAR-alpha
C. tightly bind to bile acids
D. inhibition of HMG-CoA reductase

A 35 year-old woman presents with significantly elevated LDL, elevated triglycerides and lowered HDL levels. She has a history of liver disease and is currently taking OTC Pepcid for indigestion. Which of the following would be the best treatment option for her?

a. pravastatin + niacin
b. simvastatin + niacin
d. simvastatin + cholestyramine
e. simvastatin only

You recently prescribed pravastatin for one of your patients with hyperlipidemia. All of the following are possible side effects that you might see in this patient EXCEPT:

A. decreased vitamin D synthesis
B. all of the following are possible side effects
C. rhabdomyolysis
D. myopathy
E. decreased HDL

Activation of PPAR-alpha and a reduction in the release of VLDL from the liver is a mechanism of action descriptive of:

A. bile-acid resins
B. simvastatin
C. fibrates
D. pravastatin
E. niacin