Opioids

What is the gold standard for treating chronic pain?

Opioids alone or in combination with non-opioid analgesics
What occurs in the PAG (peri-acqueductal gray)?

Midbrain processing center; high concentration of opioid receptors, modulation of pain response in descending endogenous pain suppressant pathways.
What are the three endogenous opioid agonists?
- Enkephalin
- Dynorphan
- Endorphans
What is psychotomimesis?

Psychotic-like behavior (hallucinations, dysphoria)
What are common effects of Mu receptors?

(Hint: PEAR)
- Physical dependence
- Euphoria
- Analgesia
- Respiratory depression
What are the common effects of Kappa receptors?

(Hint: SAD/M/P)
- Sedation
- Analgesia
- Diuresis
- Miosis
- Psychotomimesis
What are the common effects of Delta agonists?

(Hint: ARGH)
- Analgesic
- Releases Growth Hormone
What is the main MOA for opioids?

Opioids inhibit adenylyl cyclase, increase K+ influx, reduce Ca2+ influx, and therefore decrease neurotransmitter release

Author

Spykenard

183023

Card Set

Opioids

Description

Pharmacology

Updated

2012-11-12T02:10:54Z

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