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Opioids
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What is the gold standard for treating chronic pain?
Opioids alone or in combination with non-opioid analgesics
What occurs in the PAG (peri-acqueductal gray)?
Midbrain processing center; high concentration of opioid receptors, modulation of pain response in descending endogenous pain suppressant pathways.
What are the three endogenous opioid agonists?
Enkephalin
Dynorphan
Endorphans
What is psychotomimesis?
Psychotic-like behavior (hallucinations, dysphoria)
What are common effects of Mu receptors?
(Hint: PEAR)
Physical dependence
Euphoria
Analgesia
Respiratory depression
What are the common effects of Kappa receptors?
(Hint: SAD/M/P)
Sedation
Analgesia
Diuresis
Miosis
Psychotomimesis
What are the common effects of Delta agonists?
(Hint: ARGH)
Analgesic
Releases Growth Hormone
What is the main MOA for opioids?
Opioids inhibit adenylyl cyclase, increase K+ influx, reduce Ca2+ influx, and therefore decrease neurotransmitter release
Author
Spykenard
ID
183023
Card Set
Opioids
Description
Pharmacology
Updated
2012-11-12T02:10:54Z
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