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Which organs are the major excretory organs?
Kidneys
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Which organ serves as a temporary storage reservoir for urine?
Urinary Bladder
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Which organ transports urine from the kidneys to the bladder?
Ureters
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Which organ transports urine out of the body?
Urethra
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How many liters of fluid do the kidneys filter from the body daily?
200 Liters
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The kidneys function in the removal of what 3 things from the blood?
- Toxins
- Metabolic wastes
- Excess ions
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The kidneys function in the regulation of what 3 things?
- Blood volume
- Chemical composition
- pH
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During prolonged fasting, what process do the kidneys function in?
Gluconeogenesis
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The kidneys have endocrine functions. Which hormone plays a role in regulation of blood pressure and kidney function?
Renin
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The kidneys have endocrine functions. Which hormone plays a role in regulation of RBC production?
Erythropoietin
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They kidneys function to activate which vitamin?
Vitamin D
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Which kidney is lower, the right or the left?
Right kidney is lower than the left
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Which 4 body structures enter and exit at the hilum of the kidney?
- Ureters
- renal Blood Vessels
- Lymphatics
- Nerves
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What is the outer covering of the kidney called?
Fibrous capsule
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Which part of the kidney prevents spread and infection to the kidney?
Fibrous capsule
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What is the granular superficial region of the kidney called?
Renal cortex
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What is the cone-shaped medullary (renal) pyraminds seperated by renal columns of the kidney called?
Renal Medulla
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On the kidney, what is the tip of the pyramid called that releases urine into the minor calyx?
Papilla
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What is the funnyl shaped tube within the kidney called?
The renal pelvis
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What are the branching channels of the renal pelvis that collect urine from the minor calyces called?
Major calyces
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What are the branching channels of the renal pelvis that empty urine into the pelvis called?
major calyces
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Urine flows from the renal pelvis to the _____.
Ureter
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What are the structural and functional units that form urine?
Nephrons
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Aprox. how many nephrons are there per kidney?
~ 1 million per kidney
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There are 2 main parts of the nephrons. Which part are a tuft of capillaries?
Glomerulus
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There are 2 main parts of nephrons, which part begins as a cup-shaped glomerular (bowman's) capusule surrounding the glomerulus?
Renal tubule
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Which two structures is the renal corpuscle made up of?
Glomerulus + its glomerular (Bowman's) capsule
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Which part of the renal capsule is made up of fenestrated flomerular capillaries?
Glomerulus
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Which part of the renal corpuscle allows filterate to pass from plasma into the glomerular capsule?
Glomerulus
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Which is known as: inflammation of the kidney that involves the glomeruli?
Gomerulonephritis
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Which part of the renal tubules function in reabsorption and secretion?
Proximal convulated tubule (PCT)
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Which part of the renal tubules are confined to the cortex?
Proximal convulated tubule (PCT)
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Which part of the renal tubule are the descending and ascending limbs?
Loop of Henle
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Are the ascending or descending Loop of Henle usually thin segements?
Descending
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Are the ascending or descending Loop of Henle freely permeable to water?
Descending
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Are the ascending or descending Loop of Henle usually the thick segments?
Ascending
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Which renal tubules function more in secretion than reabsortion?
Distal convulated tubule (DCT)
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Which renal tubules are confined to the cortex?
Distal convulated tubule (DCT)
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Which part of the kidneys receive filtrate from many nephrons?
Collecting Ducts
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Which part of the kidneys fuse together to deliver urine through papillae into minor calyces?
Collecting ducts
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Which type of nephrons make up 85% of nephrons?
Cortical nephrons
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Which type of nephrons are almost entirely in the cortex?
Cortical nephrons
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Which type of nephrons make up 15% of nephrons?
Juxtamedullary nephrons
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Which type of nephrons are long loops of Henle that deeply invade the medulla?
Juxtamedullary nephrons
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Which type of nephrons are important in the production of concentrated urine?
Juxtamedullary nephrons
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Do afferent arterioles enter or exit the glomerulus?
Enter
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Do efferent arterioles enter or exit the glomerulus?
Exit
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Which structures in the nephron capillary beds are specialized for filteration?
Glomerulus
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In the glomerulus is blood pressure high OR low?
High, because afferent arterioles are larger in diameter than efferent arterioles
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In glomerulus, blood pressure is (1. high/low), because afferent arterioles are (2. smaller/ larger) in diamter than efferent arterioles.
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Are arterioles in the nephron capillary beds, high-resisitance or low-resistance vessels?
High-resistance
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Which structures in the nephron capillary beds are low-pressure, porous capillaries adapted for absorption?
Peritubular capillaries
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Which capillaries in the nephron capillary beds, arise from efferent arterioles?
Peritubular capillaries
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Do peritubular capillaries arise from afferent or efferent artierioles?
Efferent arterioles
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Which capillaries in the nephron capillary beds cling to adjacent renal tubules in the renal cortex?
Peritubular capillaries
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What do the peritubular capillaries empty into?
Venules
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Which capillaries of the nephron capillary beds empty into venules?
Peritubular capillaries
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Which structures of the nephron capillary beds are long vessels parallel to long loops of Henle?
Vasa recta
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Which structures of the nephron capillary beds arise from efferent arterioles of juxtamedullary nephrons?
Vasa recta
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Which strutures of the nephron capillary beds function in the formation of concentrated urine?
Vasa recta
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How many juxtaglomerular apparati are there per nephron?
One per nephron
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Juxtaglomerular apparatus (JGA) are important in regulation of what 2 things?
- Filterate formation
- Blood pressure
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What in the kidneys is the porous membrane between the blood and the capsular space?
Filteration membrane
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What in the kidneys allows passage of water and solutes smaller than most plasma proteins?
Filteration membrane
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The filteration memebrane consists of 3 structures, which of them is of the glomerular capillaries?
Fenestrated endothelium
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The filteration memebrane consists of 3 structures, which of them is of the glomerular capsule (podocytes with foot processes and filteration slits)?
Visceral membrane
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The filteration memebrane consists of 3 structures, which of them is gel-like and fused basal laminae of the two other layers?
Basement membrane
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The kidneys filter the body's entire plasma volume how many times each day?
60 times each day
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What in the kidneys is defined as blood plasma minus proteins?
Filterate
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Urine is what % of total filterate?
<1%
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What in the kidneys contains metabolic wastes and unneeded substances?
Urine
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What are the 3 mechanisms of urine formation?
- 1.Glomerular filteration.
- 2.Tubular reabsorption (tubules to the blood).
- 3.Tubular secretion (blood to tubules).
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During which mechanism of urine formation does all glucose and amino acids, 99% of water, salts, and other compnents return to the blood?
Tubular reabsorption (tubules to blood)
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During which mechanism of urine formation is the reverse of reabsorption and is a selective addition to urine?
Tubular secretion (blood to tubules)
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What is defined as the pressure responsible for filterate formation?
Net Filteration Pressure (NFP)
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What is defined as the volume of filterate formed per minute by the kidneys?
Glomerular Filteration Rate (GFR)
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What 3 things is the glomerular filteration rate governed by (and directly proportional to)?
- Total surface area available for filteration.
- Filteration membrane permeability.
- Net Filteration Pressure.
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How many types of mechanisms is GFR (glomerular filteration rate) controlled by?
2
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Which of the 2 mechanisms that glomerular filteration rate is controlled by, acts locally within the kidney?
Intrinsic controls
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Which of the 2 mechanisms that glomerular filteration rate is controlled by, is also known as renal autoregulation?
Intrinsic controls
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Which of the 2 mechanisms that glomerular filteration rate is controlled by, are nervous and endocrine mechanisms that maintain blood pressure, but affect kidney function?
Extrinsic controls
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Which of the 2 mechanisms that glomerular filteration rate is controlled by, includes the myogenic mechanism?
Intrinsic controls
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Which mechanism that is controlled by intrinsic controls are regulated by smooth muscle in response to stretch?
Myogenic mechanism
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If blood pressure increases, does this cause constriction or dialation of afferent arterioles?
Constriction
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Does contriction or dialtion of afferent arterioles protect glomeruli from damaging high blood pressures?
Constriction
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Does the increase or decrease of blood pressure help maintain normal gloermular filteration rate (GFR)?
BOTH
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Does the constriction or dialation of afferent arterioles help maintain normal glomerular filteration rate (GFR)?
BOTH
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If blood pressure decreases, does this cause constriction or dialation of afferent arterioles?
Dialtion
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In intrinsic controls of the regulation of glomerular filteration, which mechanism plays a role in blood pressure?
Myogenic mechanism
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Does fulterate flow rate increase in the tubule if GFR increases OR decreases?
Increases
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During intrinsic controls (tubuloglomerular feedback mechanism), because of insuffient time for reabsorption, will NaCl concentration be high OR low?
High
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In extrinsic controls of the regulation of glomerular filteration, under normal conditions at rest, are renal blood vessels contricted OR dialted?
Dialtaed
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Under extreme stress, which hormone is released by the sympathetic nervous system and is this an intrinstic or extrinstic control?
Norepinephrone and it is an extrinsic control
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Under extreme stress, which hormone is released by the adrenal medulla? And is this an intrinic or extrinsic control?
Epinephrine, extrinsic control
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Do norepinephrine and epinephrine cause constriction OR dialation of afferent arterioles, inhibiting filteration and triggering the release of renin?
Constriction
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Is the renin-angiotensin mechansim part of the intrinsic or extrinisc controls?
Extrinsic
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Angiotensinogen (a plasma globulin) is converted into angiotensin I by the release of what?
Renin
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Does angiotensin II constrict or dialate arteriole smooth muscle? Does it cause blood pressure to rise or drop?
1Constricts arteriolar smooth muscle, causing blood pressure to rise
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What does angiotensin II stimulate the reabsorption of?
Na+ (sodium)
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Angiotensin II stimulates the reabsorption of Na+, which triggers the adrenal cortex to release what?
Aldosterone
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Angiotensin II stimulates the hypothalamus to release what and activate which center?
Stimulates the hypothalamus to release ADH and activates the thirst center
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Angiotensin II (1. contricts/dialtaes) efferent arterioles, (2. increasing/decreasing) peritubular capillary hydrostatic pressure (pressure exerted by a fluid) and (3. increasing/ decreasing) fluid reabsorption.
- 1. constricts
- 2. decreasing
- 3. increasing
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Angiotensin II causes glomerular mesangial cells to contract, ( 1. increasing/ decreasing) the surface area available for filteration.
Decreasing.
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Reabsorption of which element provides the energy and the means for reabsorbing most other substances?
Na+
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Are organic nutrients reabsorbed by primary or secondary active transport?
Secondary
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What reflects the number of carriers in the renal tubules available?
Transport maximum (Tm)
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Organic nutirents are reabsorbed by secondary active transport. Excess of a substance is secreted when carriers are saturated OR unsaturated?
Saturated
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What is water reabsorbed by and aided by?
- Reabsorbed by Osmosis.
- Aided by water-filled pores called aquaporins
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How are cations and fat soluble substances reabsorbed?
By diffusion
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In the kidneys, what is the sire of most reabsorption?
Proximal convulated tubule
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In the proximal convulated tubule sodium and water make what % of reabsorption?
65%
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The proximal convulated tubules are the site of most reabsorption of what?
- 65% of Na+ and water.
- All nutrients
- Ions
- Small proteins
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In the loop of Henle, what does the descending limb reabsorb?
Water
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In the loop of Henle, what does the ascending limb reabsorb?
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