NCTI- Pharmacology- Drug List J- Hydromorphone Hydrochloride

  1. Hydromorphone Hydrochloride
    trade name
  2. Hydromorphone Hydrochloride
    Narcotic Analgesic
  3. Hydromorphone Hydrochloride
    mechanism of action
    • 1. Binds with opiate receptors in brain, altering perception and emotional response to pain.
    • 2. suppresses the cough reflex by direct action on the cough center in the medulla oblongata.
  4. Hydromorphone Hydrochloride
    • 1. moderate to severe pain
    • 2. persistent cough
  5. Hydromorphone Hydrochloride
    • 1. increased intracranial pressure
    • 2. respiratory depression / inadequacy – such as in COPD, status asthmaticus
    • 3. circulatory compromise
  6. Hydromorphone Hydrochloride
    side effects
    • CNS: sedation, dizziness, lightheadedness, somnolence, blurred vision, nystagmus
    • Cardiovascular: hypotension, bradycardia
    • Respiratory: respiratory depression or arrest, bronchospasm
    • GI: nausea / vomiting, constipation
  7. Hydromorphone Hydrochloride
    Use with caution in head injuries; the elderly, debilitated or immuno-compromised patients; COPD or other respiratory problems and those with kidney or liver dysfunction.
  8. Hydromorphone Hydrochloride
    Other CNS depressants, general anesthetics, MAO inhibitors, other opioid analgesics, sedatives, tranquilizers, and tricyclic antidepressants may potentiate the effects of Dilaudid.
  9. Hydromorphone Hydrochloride
    IV, IO, IM, SQ, PR and PO
  10. Hydromorphone Hydrochloride
    onset and duration
    IV and IM administration most common in the hospital setting – IV: onset in 10-15 minutes, peaks in 15-30 minutes and lasts 2-3 hours. IM: onset in 15 minutes, peaks in 30-60 minutes, and lasts 4-5 hours.
  11. Hydromorphone Hydrochloride
    • For Pain Control:
    • Adults: 1-4 mg IM, SQ or SLOW IV push (over at least 2-5 minutes) every 4-6 hours
    • Pediatrics: Rarely given for pain control – primarily for cough suppressant effects.

    • For Cough:
    • Adults and children > 12 years: 1 mg cough syrup PO every 3-4 hours
    • Children ages 6-12 years: 0.5 mg of cough syrup every 3-4 hours
  12. Hydromorphone Hydrochloride
    Often used in the clinical internship setting.
Card Set
NCTI- Pharmacology- Drug List J- Hydromorphone Hydrochloride
NCTI- Pharmacology- Drug List J- Hydromorphone Hydrochloride