med chem quiz 8

oral thienopyridine that irrereversibly inhibits ADP
does not inhbit cAMP

oral agent that irrereversible inhibits ADP binding to platelet receptor
for acute coronary syndrome
prodrug that bypasses CYP2C19 metabolism
potential thrombotic thrombocytopenia prupura

anti-platelet indicated for unstable angina and non-Q wave MI
integrin receptor glycoprotein IIIb/IIa receptor blocker
IV only with a longer half life
contains sulpha

anti-platelet not to be administered in same line as furosemide because of its basic content
peptide based drug - shorter half life
IV only

reversible anti-platelet for acute MI
acts by monoclonal antibody blocker of integrin receptor
administer IV stand alone line - no floaters
most common side effect is bleeding

anti-platelet that acts on thrombocytopenia
acts at the bone site
decreases megkaryocyte
inhibits cAMP phoshpodiesterase III 
inhibits ADP and collagen induced platelet aggregation

anti-platelet used for intermittent claudication (periperal vascular disease)
contraindicated in CHF patients
phoshpodiesterase inhibitor
smoking decreases by 20%

a complication of PCTA where the acute vessel recoils and post-injury arterial shrikage (constrictive remodleing)

a complication of PCTA with an increase risk of sub-acute thrombosis that can result from a non-drug coated stent

the main cause of drug coated stents that resis stenosis

material that was the first coating on a stent

ST-segment elevation in leads V1,V2,V3,I,aVL

aVR and ST segment depression in leads V4,V5,V6,II,III and a VF

suicide substrate produced from metabolism of clopidogrel

any important point to remember about clopidogrel

avoid with the use of this with clopidogrel because of the CYP2C19 inhibition

what is exposed that causes platelet aggregation and restenosis

anti-platelet prodrug used for the prevention of stroke and sickle cell disease
used for those intolerant to ASA
blood dyscrasias
inhibits ADP-induced platelet fibrinogen (nonreversible)

what occurs physically to a coronary artery resulting in a myocardial infarction

how do you resolve a blood clot in MI

how do you remove plaque

complication where you puncture the blood vessel and mandate immediate coronary bypass surgery

myocardial injury caused by the restoration of coronary blood flow AFTER an ischemic event

CYP enzyme order of clopidogrel metabolism

thrombotic therapy

no thrombus or occlusive plaque present "silent heart attack"

intervention of radiation to prevent restenosis

alternative to intravascular brachytherapy

which stents are more likely to produce late stent thrombosis