Benadryl & Phenylephrine Nasal Spray

  1. Generic name for Benadryl?
    diphenhydramine HCL
  2. What is the brand name for Benadryl?
  3. What is the class for Benadryl?
    • Antihistamine
    • Anticholinergic
  4. What is the mechanism of action for Benadryl?
    • Antihistamine
    •      Blocks Hhistamine receptors in CNS, blood vessels, respiratory and GI tracts
    •           Drowsiness
    •           Decreased capillary permeability      
    •           Decreased respiratory mucouse production
    •           Decreased stomach motility / nausea
    •           Vasoconstriction
    • Anticholinergic
    •      Decreased CNS
    •      Decreases re-uptake of dopamine in CNS
    •           Reverses extrapyrimidal reactions
  5. What are the indications and field use for Benadryl?
    Allergic reaction

    • Anaphylaxis
    •      Why - Blocks Hhistamine receptors decreasing capillary permeability & itching

    • Extrapyrimidal reactions
    •      Why - Anticholinergic in CNS decreasing activity and re-uptake of dopamine
  6. Dosage for Benadryl?
    Doseage is via slow IV push or IM


    • Anaphylaxis or Extrapyrimidal reactions 
    •      Benadryl 50mg slow IV push or IM

    • Allergic reaction with itching
    •      Benadryl 25mg slow IV push or IM
  7. Contraindications for Benadryl?
    • Known hypersensitivity or allergy
    • Acute asthma attack
    • Narrow-angle glaucoma (relative)
  8. Drug interactions for Benadryl?
    • Increased effect with other CNS depressants
    • MAOI prolong/intensify anticholinergic effects
  9. Side effects for Benadryl?
    • Paradoxical CNS excitation
    • Arryhthmias
    • Nausea / Vomiting
    • Decreased level of consciousness
    • Anaphylaxis
    • Seizures
    • Hypotension
  10. Onset of Action for Benadryl?
    IV - 5-10 minutes
  11. AZ drug box supply for Benadryl?
    2 x Benadryl 50mg in 1cc vial or prefilled syringe
  12. Generic name for Phenylephrine Nasal Spray?
    phenylephrine nasal spray 0.5%
  13. Brand name for Phenylephrine Nasal Spray?
    Neo-synephrine Nasal Spray 0.5%
  14. Class for Phenylephrine Nasal Spray?
    Topical vasoconstrictor
  15. Mechanism of action for Phenylephrine Nasal Spray?
    • Vasoconstrictor
    •      Stimulates a receptors in the blood vessels of the nasal mucosa which causes constriction which decreases the risk of nasal bleeding
  16. What are the indications and field use for Phenylephrine Nasal Spray?
    Faciliation of nasal intubation

    Why - stimulates a receptors which constricts blood vessels of the nasal mucosa
  17. Dosage of for Phenylephrine Nasal Spray?
    Mucosal - spray into each nostril

    Adult - 2-4 sprays in each nostril before attempting tube insertion
  18. Contraindications for Phenylephrine Nasal Spray?
    Known hypersensitivity / allergy
  19. Drug interactions for Phenylephrine Nasal Spray?
  20. Side effects for Phenylephrine Nasal Spray?
    • Rare with single dose, rarely absorbed systemically from nasal instillation 
    • Hypertension
    • Tremors
  21. Onset of action for Phenylephrine Nasal Spray?
  22. Peak effect for Phenylephrine Nasal Spray?
    30 minutes
  23. Duration of action for Phenylephrine Nasal Spray?
    30 minutes to 4 hours
  24. AZ drug box supply for Phenylephrine Nasal Spray?
    1-2 bottles 0.5% 15ml bottle
Card Set
Benadryl & Phenylephrine Nasal Spray
Phoenix College Paramedic 2012 2013 Drug Profiles - Benadryl & Phenylephrine Nasal Spray