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Endogenous drugs involved in bone homeostasis?
- parathyroid hormone
- vitamin D
- calcitonin
- glucocorticoids
- estrogen
- biophosphonates
- floride
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Teriparatide?
Parathyroid hormone (injection)
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clinical uses of vitamin D?
- Helps store calcium.
- Formed in liver and kidneys through light and diet as well. Stored in adipose tissue.
-
clinical use of glococorticoids?
Antagonize vit D, stimulate mobilization of calcium
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Calcitonin?
- Peptide hormone secreted from thyroid parafolicular cells
- nasal sprays or injection, calcitonin salmon
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soltamox?
blocks estrogen for cancers
-
raloxifene?
estrogen that reduces fracture incidents
-
alendronate?
biophosphonate
-
etidronate?
biophosphonate
-
risedronate?
biophosphonate
-
ibandronate?
biophosphonate
-
clinical use of biophosphonates?
- Reduce formation and resorption of bone.
- Post menopausal women
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Drugs for muscle spasm?
Benzodiazepines, opioids, polysynaptic inhibitors, NSAIDs, and botulinum toxin
-
cyclobenzaprine?
polysynaptic inhibitor
-
carisoprodol?
polysynaptic inhibitor
-
metaxalone?
polysynaptic inhibitor
-
clinical uses of polysynaptic inhibitor?
- Decrease in a motor neuron stimulation
- general CNS depressant effect
-
Side effects of polysynaptic inhibitors?
- General CNS depressant effect (sedation and drowsiness, delayed psychomotor response)
- amnesia
- residual effect (hangover)
- GI/CV/Respiratory depression
- behavioral changes
- tolerance
- addiction/dependence
- withdrawal and rebound anxiety
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