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What is the difference between male and female urethras?
Male urethra connected to eject sperm. Female just use for pee.
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2 major layers of kidney?
Renal Cortex
Renal Medulla
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Where is left kidney located?
T12-L3.
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Where is right kidney located?
L1-L4.
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What vessels supply waste to kidneys?
Renal artery.
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What removes waste from kidneys?
Ureter.
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What part of the nephron is water permeable?
Descending loop.
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What part is water permeable depending on ADH?
Collecting ducts.
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What are the two types of nephrons?
Cortical
Juxtamendullary
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Which is the shorter of the two?
A) Cortical
B) Juxtamedullary
A) Cortical
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Where is the parietal epithelium on the bowman's capsule?
The outside of the "bulb".
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Where is the visceral epithelium?
On the proximal/distal tube structures.
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What's a podocyte?
Visceral epithelial cells that wrap around the glomerulus and filter fluid.
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What are parts of the juxtaglomerular apparatus?
Macula cells
Juxtaglomerular cells
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Basic function of the kidney?
Acid/base balance
Osmolarity.
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What does ADH do?
Allows body to reabsorb water.
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What does aldosterone do to the kidney?
Allows more salt to be reabsorbed.
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How does kidney regulate osmolarity?
- Filtration
- Reabsorption
- Filtration
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What is GFR?
Glomerulus Filtration Rate
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Afferent arteriole?
The arteriole where blood is coming in.
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Efferent arteriole?
Part where blood is going back out.
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What happens to GFR when Aff. arteriole is closed?
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What happens to GFR when Aff. arteriole is open?
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What happens to GFR when Eff. arteriole is open?
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What happens to GFR when Eff. arteriole is closed?
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What does ANP do to filtration?
- Increases GFR
- inhibits renin
- decreases sodium reabsorption
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What triggers ANP?
Angiotensin II
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What is Myogenic Mechanism?
The response to changing blood pressure to keep the flow in the vessels constant.
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What is tubuloglomerular feedback?
Changes in GFR are detected by the renal tubule, which sends feedback signals to the glomerulus, bringing GFR to a normal level.
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What is the JGA?
JuxtaGlomurular Apparatus.
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What is the macula densa?
Cells around the distal tube. Detect water volume. If low, release Renin.
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What part of the nephron reabsorbs 60-70% of fluid?
Proximal tube.
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What occurs in the decending loop of henle?
Water to body.
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What occurs in the thin ascending loop?
Na+ ions back to body.
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What occurs in the thick ascending loop?
K+ ions back to body.
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What occurs in the Distal Convoluted Tubial?
- Regulates pH. (Na+, HCO3-)
- Regulates sodium, potassium, calcium levels
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What symport is found on the apical membrane of the DCT?
NaCl symport.
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What occurs in the collecting duct?
Water regulation.
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What are principal cells in the collecting duct?
Allows transport of Na and K and water.
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What are intercalated cells in the collecting duct?
Acid-Base homeostasis.
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What is the RAAS system stand for?
Renin Angiotensin Aldosterone System.
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What is the RAAS system do?
Regulate long term blood pressure and volume.
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Where is angiotensin made?
Liver
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Where is converted to angiotensin I? What enzyme does this?
Kidney. Renin.
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Where is angiotensin I converted to angiotensin II? What enzyme does this?
Lungs. ACE.
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What does angiotensin II do to the brain?
Release ADH. Thrist.
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What does angiotensin II do to the adrenal gland?
Release aldosterone.
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Other than stimulate the brain and the adrenal gland, what else does angiotensin II do?
Vasal constriction.
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What does ADH do to the kidney?
More water to be reabsorbed.
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What does aldosterone do to the kidney?
Allows more salt to be reabsorbed.
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What is the counter current mechanism?
When water is filtering out from the loop of henle, sodium pulls water back in through osmosis.
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What is renal plasma clearance?
The amount of blood filtered by the kidney.
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What is dialysis?
Kidney failure.
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What is respiratory acidosis? Cause? Solution?
Problem with the lungs. Blood too acidic. Kidneys hold onto the base.
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What is metabolic acidosis? Cause? Solution?
Problem with the kidneys. Blood too alkaline. Lungs hold onto CO2 (base).
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Respiratory alkalosis. Cause? Solution?
Something wrong with lungs. Blood too alkaline. Kidneys release base (Hco3-)
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Metabolic alkilosis? Cause? Solution?
Something wrong with kidneys. Blood too alkaline. Lungs keep Co2 (acid).
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What is creatine phosphate? (immediate source of ATP?)
It can donate phosphate group to ADP making ATP during intense muscular effort.
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What happens in anaerobic glycolysis?
Glucose > Pyruvate > Lactate
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How many ATP from glycolysis?
2
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What happens in aerobic glycolysis?
Goes to TCA cycle.
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What goes on in TCA cycle?
Pyruvate > ACoA > Citrate > Isocitrate > Alpha-Gluterate> Succinocule > Succinate > Fumaric > Malate > Oxaloacitate > Citrate.
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What comes after Citrate in TCA cycle?
Isocitrate.
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What comes after Isocitrate in TCA cycle?
Alpha-gluterate.
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What comes after Alpha-gluterate in TCA cycle?
Succinocule.
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What comes after Succinoclue in TCA cycle?
Succinate.
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What comes after Succinate in TCA cycle?
Fumaric.
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What comes after Fumaric in TCA cycle?
Malate.
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What comes after Malate in TCA cycle?
Oxaloacitate.
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What comes after Oxaloacitate in TCA cycle?
Citrate.
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How many ATP from ETC?
36.
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How many ATP form Kreb's/TCA cycle?
38
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What steps in glycolysis is ATP used?
1, 3
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What steps in glycolysis is ATP produced?
7, 10.
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Final electron acceptor in anaerobic glycolysis?
Pyruvate.
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What product from glycolysis goes into TCA cycle?
Pyruvate.
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Where is glycogenesis activated?
Liver.
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What's glycogenesis for? What hormone is involved?
Response to high blood glucose. Stores glucose in glycogen for storage. Insulin.
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What is Glycogenolysis? What hormone is involved?
Breakdown of glycogen to glucose. Glucagon.
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What happens in Glycogenolysis?
Glucose-1 phosphate to glucose-6 phosphate.
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What is Gluconeogenesis?
Make glucose from non-carb sources, like amino acids.
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What is Beta oxidation?
Fats broken down for energy.
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What is lipolysis?
Hydrolysis of lipids.
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What is Lipogenesis?
A-CoA to fats.
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What is ketosis?
State where being has elevated levels of ketone bodies from fat breakdown for energy.
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End product of protein metabolism?
Urea. Ammonium. Creatine.
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What is ammonia turned into in urea cycle?
Urea.
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What are fat soluble vitamins?
Vitmains A, D, E, K that are absorbed in GI tract with help from lipids. Doesn't get extracted through urine.
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What two hormones stiumlate gluconeogenesis?
Cortisol/glucagon.
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What electrolytes are inside the cell?
K+, PO43-, Mg++
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What electrolytes are outside cell?
Na, Cl, Ca.
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What happens in the thick ascending loop?
Reabsorption.
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Is the thick ascending loop water permeable?
No.
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What are the 3 layers between glomerulus and nephron?
- Endothelium
- Basement membrane
- Epithelium (podocytes)
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What are the 3 active functions of nephron?
- Filtration
- Secretion
- Reabsorption
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What is the passive result of the kidney regulating osmolarity?
Excretion.
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What structure produces sperm?
Testes
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Where does sperm mature?
Epididymis
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Where is non-viable sperm reabsorbed?
Seminal vesicles.
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What are the 3 parts of the urethra?
Spongy, Prostatic, Ejaculatory duct.
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What are the 2 cells that assist in growth and maturation of the spermatogonia?
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What are sertoli cells also called?
Nurse cells.
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What are leydig cells also called?
Interstitial cells.
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How does the balls drop?
The testes shift places as the fetus grows.
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When do the balls drop?
7 months to birth.
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What happens in the seminiferous tubules?
Sperm maturation.
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What cells mature sperm?
Leydig and Sertoli cells.
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What is spermatogenesis?
The process of maturation of sperm.
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What is spermiogenesis?
The last stage of spermatogenesis. Spermatids mature into sperm.
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What is mitosis?
Copy all 23 pairs of chromosomes into a cell.
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What is meiosis?
Copy just one side of the 23 pairs of chromosomes into a cell.
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What are sertoli cells for?
Nurse sperm cells through process.
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What are leydig cells for?
LH stimulates them to release testosterone.
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What does FSH do to male gonads?
Make sperm
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What does LH do to male gonads?
Make testosterone.
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What do seminal vesicles do?
Secrete the fluid that makes sperm "semen"
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What do the prostate gland do?
Secrete the "white" liquid that is basic. It fights the acidity of the vag.
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What does bulbourethral gland make?
"pre-cum" makes the sperm travel easier.
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What produces eggs?
Ovaries.
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Where do eggs mature?
Ithmus.
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What is the follicle?
The place where the egg is.
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What is the corpus luteum?
Follicle turns into this after ovulation. Secretes progesterone and estrogen.
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What is corpus albicans?
Corpus luteum turns into this after it dies.
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What cells used in maturing the egg?
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Granulosa cells do what?
Form a layer around the follice.
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Theca cells do what?
Produce androgens that combine with granulosa cells to make estradiol.
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What do suspensory ligaments hold up?
Ovaries.
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What do broad ligament hold up?
Uterus from moving up and down.
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What do ovarian ligament do?
connects the ovary to uterus.
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What stages are frozen?
Metaphase I
Prophase II
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What is oogenesis?
Creation of an egg.
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What receptors are in schincters?
Alpha.
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What receptors are in the bladder?
Beta.
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"pril" in a drug means what?
ACE blocker.
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Which is fast to react? Lungs or kidney?
Lungs.
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What does the drug Diamax do?
Diuretic.
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Sterocilia is for?
Reabsorb sperm.
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What is cryptorchidism?
Balls didn't drop.
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What is hydrocele?
Fluid around a body cavity.
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What is a gubernaculum?
bungee cord that holds down testes to sack.
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What does the cremaster muscle do?
Moves balls up n down.
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What's in the sperm head?
The choromomes.
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What's in the sperm middle?
The ATP to make it move.
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What controls erections?
C) PNS
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What controls ejaculations?
D) SNS
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Salping o'pe rectemy deals with what?
ovaries/fellopian tubes
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Mesovarium secretes what?
Serious fluid.
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