Path Test 2: WBCs

  1. Infectious Mononucleosis
    Infection of B-ells with EBV through the CD21 protein
  2. Pelger-Huet Anomaly:
    AD or AR?
    Neutrophils appear?
    Neutrophils function?
    • AD
    • Bilobed, unsegmented neutrophi nuclei
    • Normal neutrophil function
  3. Acquired Pelger-Huet anomaly is seen in
    Myelodysplasia or myeloid leukemia
  4. Neutrophils:
    Light blue cytoplasmic inclusions
    RNA remnants or rER
    Observed in infections and inflammatory states
    Dohle Bodies
  5. Neutrophil nuclear hypersegmentation:
    > 5 lobes
    Associated with?
    B12/Folate deficiency
  6. Kostmann Syndrome
    • Inherited Deficiency
    • Neutropenia
  7. Neutropenia Tx:
    Broad-spectrum antibiotics
    GCSF= ?
    Granulocyte transfusion (severely neutropenic pats with fever or infection unresponsive to antibiotics or antifungal agents)
  8. Myeloproliferative Neoplasms (Chronic Myeloproliferative Disorders)
    • CML (Chronic Myelogenous Leukemia)
    • PV (Polycythemia Vera)
    • ET (Essential Thrombocythemia)
    • Primary Myelofibrosis
  9. 3 Stages of CML
    • CAB
    • Chronic Phase
    • Accelerated Phase
    • Blast Phase
  10. t(9;22)
    Philadelphia chromsome found in?
  11. How do you differentiate CML from Leukemoid rxn?
    Which one has more leukocyte alkaline.
    • CML has basophilia, eosinophilia, and nucleated RBCs.
    • Leukemoid rxn has mainly banded PMNs while CML has the whole spectrum.
    • Leukmoid has more Leukocyte alkaline
  12. Drug directed against abnormal tyrosine kinase in CML.
    Imatinib (Gleevec)
  13. Polycythemia Vera is ____
    3 increased cell types
    Faster or slower blood flow?
    • Increased RBC (>Hct 60%); slower blood flow
    • Erythroid, Granulocytic, and megakaryocytic cells are all increased
  14. Essential Thrombocytopenia (ET) is a hematopoietic stem cell disorder that primarily affects
    Megakaryocytic cells (Platelets are increased, Giant platelets in the blood)
  15. Plateles more than 450k
    Essential Thrombocythemia
  16. Hypercellualr marrow with large dysplastic and clustering megakaryocytes
    Primary myelofibrosis
Card Set
Path Test 2: WBCs