-
quad screen
AFP, hCG, uE3, dimeric inhibin A
-
AFP
- made by fetal liver
- inc= NTD
- dec= Downs, Turners
-
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uE3
unconjugated estriol produced by fetal liver and placenta
-
Dimeric Inhibin A
made by placenta
-
2nd trimester quad screen:
dec AFP and uE3
inc hCG and Inhibin-A
2: dec AFP and uE3inc hCG and Inhibin-A
1- dec PAPP-A, inc bhCG, inc NT
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trisomy 18
2nd trimester quad screen:
1st trimester screen
2: dec AFP, uE3 and hCG
1: dec PAPP-A, bhCG increased NT
-
1st trimester screening
- for pregnancys at risk of Downs of trisomy 18
- performed at 11-14 weeks
-
1st trimester screening results for Downs
- decreased PAPP-A (MOM 0.40)
- elevated beta hCG
- **combined with nuchal tranlucency test gives 82% detection rate**
-
increased nuchael thickness
- trisomy 21, 18, 13
- triploidy
- Turners (45X)
-
key event triggering puberty
pulsatile release of GnRH from the HT
-
RLS for steroidogenesis
levels and functionality of StAR protein (shuttles cholesterol across mtch mem
-
when does decidualization occur
after endometrial stroma has been exposed to Progesterone for about 10 day, during the end of the mid secretory stage
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