med chem quiz 7

  1. these reduce the occurence of nonfatal MI but have no significant effects on other adverse CV outcomes
  2. new mechanism of action by which fibrates may act
    inhibition of the T1Rs, G protein coupled receptors that underlie sweet and umami taste
  3. fibric acid derivative
    indicated for type III, IV and V hyperlipidemias
    MOA unknown but appears to accelerate VLDL catabolism
    clofibrate - atromid-S
  4. fibric acid derivative
    type IV and V hyperlipidemia
    inhibits peripheral lipolysis, decreases hepatic extraction of free fatty acids
    significant enterohepatic recirculation
    gemfiborzil - lopid
  5. fibric acid derivative
    appears to inhibit triglyceride and VDLD synthesis
    minimally inhibits the glucoronidation of statins
    fenofibrate - tricor and lipofen
  6. bile acid sequestrants
    forms insoluable complex with fatty acids
    anion-exchange resins
    for elevated LDL with primary hyperlipidemia
    cholestyramine resin - LoCHOLEST
  7. bile acid sequestrant indicated for elevated LDL and digitalis toxicity
    anion exchange resin polymer derived from poly-epichlorohydrin and alkylated with quaternary ammonium compounds
    colestipol HCL - colestid
  8. bile acid sequestrant used for elevated LDL type IIa hyperlipidemia in combination therapy
    colesevelam HCL - welchol
  9. bile acid sequestrant indicated for treatment of hyperphosphatemia with end-stage renal disease
    new for summer of 2004
    sevelamer - renagel
  10. miscellaneous agent that doesn't have hypolipidemic effects
  11. miscellaneous anti-hyperlipidemic agent indicated for patients with no suspected cardiovascular disease with type IIa and IIb ypercholesterolemia in which diet and other drug therapy is unsuccessful
    stimulates the liver to increase catabolism and excretion of cholesterol and its biliary decragadation products
    dextrothyroxine sodium - choloxin
  12. lipase inhibitor for hyperlipidemia that inhibits the lipase enzyme by acylation of the enzye active site nucleophile
    ezetimibe - zetia
  13. omega-3 acid ethyl esters indicated for adjunct to reduce very high triglycerides in adults
    isolated from fish
  14. vasopressor used for hypovolemic or septic shock by blocking beta 1 and beta 2 adrenergic agonist
    isoproterenol HCL - isuprel
  15. vasopressor agent used for hemodynamic imbalances caused by CHF, MI, renal failure
    5 minute onset, T1/2 - 2 minutes
    dopamine HCL - intropin
  16. vasopressor indicated for the restoration of BP in acute hypotensive states
    norepinephrine - levophed
  17. vasopressor indicated for acute ventricular standstill, cardiac arrest
    epinephrine - susphrine
  18. vasopressor agent indicated for cardiac decompensation from organic heart disease or post-surgical
    dobutamine - dobutrex
  19. vasopressor agent indicated for acute hypotensive states: spinal anesthesia, complete heart block
    most urinary excretion as unchanged drug
  20. pheochromocytoma diagnostic test where catecholamine levels are normally suppressed but not in this tumor
    clonidine test
  21. diagnostic test where the release of catecholamines from the tumor leads to increased plasma levels
    glucagon test
  22. drug for pheochromocytoma prior or post surgical that is a competitve antagonist of alpha adrenergic receptors
    rapid action and short duration
    phenotalmine - regitine
  23. drug for pheochromocytoma that irreversibly blocks alpha adrenergic receptors producing "chemical sympathectomy"
    phenoxybenzamine - dibenzyline
  24. agent used to treat pheochromocytoma by inhibiting tyrosine hydroxylase with possible side effects of drooling, tremors and speech difficulty
    metyrosine - demser
  25. this prevents the closure of patent ductus at birth
    endogenous prostaglandins
  26. drug used to keep duct open in patent ductus by producing vasodilation and relaxing the ductus smooth muscle and inhibit platelet aggregation
    prostaglandin E1 - alprostadil
  27. drug used to keep a closed duct in patent ductus by inhibiting cyclooxygenase that is responsible for prostanglandin synthesis
    indomethacin sodium - indocin IV
  28. drug used to keep a closed duct in premature infants patent ductus by inhibiting cyclooxygenase that is responsible for prostanglandin synthesis,
    ibuprofen lysine - neoProfen
  29. The three ways to recognize symptoms of stroke
    • 1. ask the individual to smile
    • 2. ask the person to talk
    • 3. ask the person to raise both arms
  30. thrombi consisting of mainly fibrin and red blood cells
  31. thrombi consisting of mainly platelet aggregrates
  32. play an important role in hemostasis and thrombus formation
  33. antiplatelet that works by inhibition of cyclooxygenase.
    low dose is important so you don't disrupt production of prostacyclin
  34. antiplatelet indicated for post MI prevention of sudden cardiac death and rheumatic mitral valve stenosis induced clotting by competitively inhibiting prostaglandin and thromboxane synthesis preventing platelet aggregation
    sulfinpyrazone - anuturane
  35. antiplatelet used for prevention of MI and stroke-in combo with ASA by inhibiting phosphodiesterase inhibition leading to increased cAMP
    dipyridamole - persantine
  36. antiplatelet used for PCTA with and without stents, reserved for use in those intolerant to ASA by inhibiting ADP induced platelet fibrinogen binding and aggregation.
    watch out for blood dyscrasias
    ticlopidine HCl - ticlid
  37. dose limitd by peripheral flushing, itching and rash inhibits lipolysis in adipose tissue, decreasing triglycerides esterification in the liver
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med chem quiz 7
quiz 7