med chem quiz 7

these reduce the occurence of nonfatal MI but have no significant effects on other adverse CV outcomes

new mechanism of action by which fibrates may act

fibric acid derivative
indicated for type III, IV and V hyperlipidemias
MOA unknown but appears to accelerate VLDL catabolism

fibric acid derivative
type IV and V hyperlipidemia
inhibits peripheral lipolysis, decreases hepatic extraction of free fatty acids
significant enterohepatic recirculation

fibric acid derivative
appears to inhibit triglyceride and VDLD synthesis
minimally inhibits the glucoronidation of statins

bile acid sequestrants
forms insoluable complex with fatty acids
anion-exchange resins
for elevated LDL with primary hyperlipidemia

bile acid sequestrant indicated for elevated LDL and digitalis toxicity
anion exchange resin polymer derived from poly-epichlorohydrin and alkylated with quaternary ammonium compounds

bile acid sequestrant used for elevated LDL type IIa hyperlipidemia in combination therapy

bile acid sequestrant indicated for treatment of hyperphosphatemia with end-stage renal disease
new for summer of 2004

miscellaneous agent that doesn't have hypolipidemic effects

miscellaneous anti-hyperlipidemic agent indicated for patients with no suspected cardiovascular disease with type IIa and IIb ypercholesterolemia in which diet and other drug therapy is unsuccessful
stimulates the liver to increase catabolism and excretion of cholesterol and its biliary decragadation products

lipase inhibitor for hyperlipidemia that inhibits the lipase enzyme by acylation of the enzye active site nucleophile

omega-3 acid ethyl esters indicated for adjunct to reduce very high triglycerides in adults
isolated from fish

vasopressor used for hypovolemic or septic shock by blocking beta 1 and beta 2 adrenergic agonist

vasopressor agent used for hemodynamic imbalances caused by CHF, MI, renal failure
5 minute onset, T1/2 - 2 minutes

vasopressor indicated for the restoration of BP in acute hypotensive states

vasopressor indicated for acute ventricular standstill, cardiac arrest

vasopressor agent indicated for cardiac decompensation from organic heart disease or post-surgical

vasopressor agent indicated for acute hypotensive states: spinal anesthesia, complete heart block
most urinary excretion as unchanged drug

pheochromocytoma diagnostic test where catecholamine levels are normally suppressed but not in this tumor

diagnostic test where the release of catecholamines from the tumor leads to increased plasma levels

drug for pheochromocytoma prior or post surgical that is a competitve antagonist of alpha adrenergic receptors
rapid action and short duration

drug for pheochromocytoma that irreversibly blocks alpha adrenergic receptors producing "chemical sympathectomy"

agent used to treat pheochromocytoma by inhibiting tyrosine hydroxylase with possible side effects of drooling, tremors and speech difficulty

this prevents the closure of patent ductus at birth

drug used to keep duct open in patent ductus by producing vasodilation and relaxing the ductus smooth muscle and inhibit platelet aggregation

drug used to keep a closed duct in patent ductus by inhibiting cyclooxygenase that is responsible for prostanglandin synthesis

drug used to keep a closed duct in premature infants patent ductus by inhibiting cyclooxygenase that is responsible for prostanglandin synthesis,

The three ways to recognize symptoms of stroke

thrombi consisting of mainly fibrin and red blood cells

thrombi consisting of mainly platelet aggregrates

play an important role in hemostasis and thrombus formation

antiplatelet that works by inhibition of cyclooxygenase.
low dose is important so you don't disrupt production of prostacyclin

antiplatelet indicated for post MI prevention of sudden cardiac death and rheumatic mitral valve stenosis induced clotting by competitively inhibiting prostaglandin and thromboxane synthesis preventing platelet aggregation

antiplatelet used for prevention of MI and stroke-in combo with ASA by inhibiting phosphodiesterase inhibition leading to increased cAMP

antiplatelet used for PCTA with and without stents, reserved for use in those intolerant to ASA by inhibiting ADP induced platelet fibrinogen binding and aggregation.
watch out for blood dyscrasias

dose limitd by peripheral flushing, itching and rash inhibits lipolysis in adipose tissue, decreasing triglycerides esterification in the liver