MODA Drugs (1)

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Pertussis toxin

Causes ADP-ribosylation of α_isubunit of G protein, preventing activation of G_iwhen stimulated
Lidocaine
- Local anaesthetic
- Binds to and stabilises inactivated state of Na⁺ channels
- Use and voltage dependence
Benzocaine
- Local anaesthetic
- Blocks Na⁺channels independent of pH
Quinidine
- Slow in, slow out LA
- Use dependence at low rates of stimulation
Tetrodotoxin
- Blocks Na⁺channels from the outside
- Has guanidinium group
Bay K 8644
- Calcium agonist
- Type of DHP
Nifedipine
- Calcium antagonist
- Type of DHP
Verapamil

Ca²⁺channel blocker
Diltiazem

Ca²⁺channel blocker
Glibenclamide
- Orally acting hypoglycaemic agent
- Closes KATP channel by acting on SUR
- Stimulates insulin release
- Treatment of Type II diabetes
α-bungarotoxin
- Nicotinic Ach receptor antagonist at nmj
- Snake venom
- Causes paralysis and respiratory failure
Cholera Toxin
- AB toxin
- ADP-ribosylates the Gα_i subunit, so unable to inhibit adenylyl cyclase production of cAMP
Ethinylestradiol
- Used in contraceptive pills
- Natural form of oestrogen
Minoxidil
- NO agonist
- Potassium channel opener
- Used for hypertension
- Promotes hair regrowth
Nicorandil
- Increases formation of cyclic GMP
- K+ATP channel opener
- Vasodilator
- Treats angina
Norethisterone
- Used in contraceptive pill
- Progestogen
Prednisolone
- Synthetic glucocorticoid receptor agonist
- Irreversibly binds
Tamoxifen
- Oestrogen receptor antagonist in breast tissues
- Agonist in others
- Therapy for breast cancer
Tyrphostins
- Tyrosine-kinase inhibitor
- Inhibits EGFR
Adenosine
- purine nucleoside
- inhibitory neurotransmitter
- Receptors are 7 transmembrane spanning G-protein coupled receptors
Atropine

smooth muscle muscarinic receptor antagonist
Benzylcholine Mustard

irreversibly alkylates the muscarinic receptor
d-Tubocurarine

skeletal muscle nicotinic receptor antagonist
Isoprenaline

β-adrenoceptor agonist
Spironolactone

Aldosterone receptor antagonist

Author

yl456

180169

Card Set

MODA Drugs (1)

Description

Mechanism and effect

Updated

2013-03-26T21:18:53Z

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