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Test 2 Micro: (Ppts 15-16)
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Name the 3 bacteria we studied that contain mycolic acids.
Mycobacterium (longest)
Nocardia
Cornybacterium (shortest)
Mycolic Acid
a-alkyl-B-hydroxylated fatty acids
Mycobacterium: Stain, shape
AFB
What can cleave mycolic acid chans into C-22 to C-26 fatty acid methyl esters?
Pyrolysis
Mycobacterium have a high content of what in their DNA?
G-C% content
Mycobacterium growth is
slow
What drug impacts the biosynthesis of mycolic acid
Isoniazid
What drug impacts the biosynthesis of arabinogalactan?
Ethambutol
Mycobacterium tuberculosis:
Intracellular or extracellular?
Prevents what?
Intracellular in unactivated macrophages.
Prevents fusion of phagosome with lysosomes
Pathology of tuberculosis is due to?
CMI response (disease primarily from host response to infection rather than specific virulence factors).
Natural reservoir of TB?
Humans (1/3 of worl is infection)
TB migrates to ____ lymph nodes. Can see granulomas and _____
hilar lymph nodes
granulomas and foam cells
Ghon Complex
Lesion in lung (tubercle/small granuloma) + enlarged lymph nodes
Most TB cases are restricted to the ____ in immune competent persons
lung
Tuberculin skin test is read by
presence or absence of induration at injection site
Alternative to TB skin test, based on quantificatoin of interferon-y
Quiantiferon-TB Gold Test
Acid-Fast Stain
Fix bacteria to microscope slide
Carbofuschin (w/ or w/o heat)
Decolarize with acid alcohol
Counter stain (methylene blue or brilliant green)
NTM (Nontuberculous Mycobacterum)
Swimming pool granuloma
M. marinum
Chronic infectin of skin an peripheral nerves
Leprosy
Two types of leprosy:
Tuberculoid
: benign, non-progressive
Lepromatous: Malignant, progressive
Which type of leprosy has few AFB in lesions and a positive lepromin skin test?
Tuberculoid leprosy (strong CMI and normal Ig levels)
Which type of leprosy has many AFB in skin lesions and anegative lepromin skin test?
Lepromatous leprosy (Deficient CMI, strong Ab response)
Author
BrookeNH10
ID
180107
Card Set
Test 2 Micro: (Ppts 15-16)
Description
Mycobacterium, TB CC
Updated
2012-10-26T21:06:58Z
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