PNS - People

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    • Santiago Ramón y Cajal
    • Discovered neurons
    • Explained why brain pathways were "crossed"
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    • Hilde Mangold and Hans Spemann
    • Discovered the organizer by transplanting a second one into an embryo, noting it was sufficient to induce a second nervous system
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    • Viktor Hamburger, Rita Levi-Montalcini, Stanley Cohen
    • Discovered NGF
    • Hamburger also in chicken with leg cut off experiment
    • Hamburger/Levi-Montalcini also in mouse tumor in developing chick experiment
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    • Sydney Brenner, John Sulston, H. Robert Horvitz
    • Used C. elegans as a model organism for molecular genetic studies and studied neuronal cell death lineages in C. elegans (ced-9, ced-3, ced-4)
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    • Stanley Korsmeyer
    • Overexpression of Bcl-2 due to chromosomal translocation; apoptosis goes down when this happens, leading to human B-cell leukemia
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    • Joseph Erlanger, Herbert Spencer Gasser, George Bishop
    • Inserted recording electrodes on dorsal roots and shocked sensory nerve in periphery; found compound action potential (alpha, delta, C fibers)
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    • Charles Scott Sherrington and Edgar Douglas Adrian
    • Nobel prize for work on neurons and sensation
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    • Dr. Marcus Raichle
    • Pioneered PET at WashU
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    • Einstein
    • Genius
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    • Donald Hebb
    • Long-term differentiation; cells that fire together wire together
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    • James Olds
    • Electrically stimulated nucleus accumbens in rats --> Reward center (rats crossed electrical grid for stimulation)
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    • Victor McKusick
    • Cataloged many human genetic diseases, including Marfan syndrome
Card Set
PNS - People