Pharm 1

–  Vasoconstriction

–  Increased peripheral resistance

•  Both result in increased blood pressure (BP)

–  Pupil dilation (mydriasis)

–  Closure of the internal sphincter of the bladder

• –  Decreased release of NE, reducing sympathetic
• outflow from brain

–  Vasodilation

–  Tachycardia

–  Increased myocardial contractility

–  Increased release of renin

–  Increased lipolysis

• – 
• ** Bronchodilation

–  Vasodilation

–  Slightly decreased peripheral resistance

–  Increased muscle and liver glycolysis

–  Increased release of glucagon

–  Relaxation of uterine smooth muscle

–  Skeletal muscle contraction

–  Short duration of action

–  Not effective orally

–  Do not cross BBB

–  Long duration of action

–  Can be given orally

–  Cross BBB

•    Mad as a hatter

•    Blind as a bat

•    Red as a beet

•    Dry as a bone

Adrenergic Agonists, Nonseletive

Phamacodynamics: Stimulates CV, Sking & viscera, respiratory receptors

• Use:
• Anaphylactic Shock
• Cardiac Emergencies
• Asthma
• Glaucoma

• Contraindications:
• Hypersensitivity
• Active Labor
• Closed angle glaucoma
• general anesthesia
• Severe organic cardiac disease
• Shock other than anaphylaxis

• Common Adverse Effects:
• Fatigue
• Sleep Disturbances
• Tremor
• Weakness
• Hyperglycemia
• Tachycardia

• Serious Adverse Effects:
• Cardiovascular Stimulation

• Nursing Interventions:
• Monitor CV Status Closely
• Schedule doses to min. sleep disruption
• Allow appetite and meal times to coincide

• Adrenergic antagonist
• Alpha

Pharmacodynamics:

• -Decreases sympathetic tone of vasculature -Dilate arterioles and veins
• -Lowers supine and standing BP