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Lipoproteins

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  1. What is inside (2) and outside (3) of lipoprotein? 
    • Inside: cholesterol esters and TAGs
    • Outside: free cholesterol + phospholipids and apolipoproteins
  2. What are the 4 main functions of apolipoproteins?
    • 1. Structural
    • 2. Enzyme activators
    • 3. Receptor site binders
    • 4. Receptor site blockers
  3. Where do you find apoB100? (3)

    Function?
    VLDL, IDL, LDL

    Structural protein for VLDL; ligand for LDL receptor
  4. Where do you find apoB48?

    Function (2)
    Chylomicrons, chylomicron remnants

    Function: structural protein of chylomicrons, lacks LDL-R binding domain and can't bind to LDL R
  5. Where do you find apoE? (5)

    Function?
    Chylomicrons/remnants, VLDL, IDL, HDL

    Ligand for binding IDL to LDL-R and LRP
  6. Where do you find Apo A-1?

    Function?
    chylo, HDL

    Structural protein of HDL, activates LCAT/PCAT (forms CE)
  7. What do chylomicrons contain? Chylomicron remnants?

    VLDL? IDL? LDL?

    HDL?
    Chylomicrons contain B48, apoE, apoAI, apoCII

    Remannts: ApoB48, apoE

    VLDL, IDL: apoB100, apoE, apoCII, LDL: only apoB100.

    HDL: ApoA1, CII, E
Author
emmayarewhy
ID
179592
Card Set
Lipoproteins
Description
lipoproteins
Updated

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