-
indications for glucocorticoids?
- arthritis
- SLE (lupus)
- allergy disorders
- asthma
-
adverse effects of glucocorticoids
- adrenal insufficiency
- osteoporosis
- ^ risk for infection
- muscle wasting
- thin skin
- F/E imbalance
- glucose intolerance
-
drug interactions with glucocorticoids?
- NSAIDs
- insulin, hypoglycemics
- vaccines
- thiazide and loop diuretics
-
special implications re: glucocorticoids?
- never stop abruptly
- need higher doses @ times of stress
-
s/sx of RA?
- autoimmune inflammatory disorder
- joint stiffness & pain
- swollen, tenderness, warm
-
DMARDs?
disease modifying antirheumatic drugs
-
drug therapy for RA? first choice?
DMARDs: methotrexate.
-
sulfasalazine (Azulfidine). indications? actions? side fx?
- RA or IBD
- slows progression of joint deterioration
- side fx: GI upset, rash, urticaria
-
methotrexate: adverse fx?
- toxicities
- GI ulcers
- bone marrow suppressionhepatic fibrosis
-
nursing implications for methotrexate?
- monitor kidney and liver function.
- (causes bone marrow suppression)
-
hydroxychloroquine (Plaquenil): uses, adverse effects?
- rheumatoid arthritis
- *monitor for visual disturbances.common to have retinal damage
-
enteracept (Enbrel)- treatment for? adverse fx?
- TNF blocker.
- delays progression of joint damage
- administered subQ
- adverse fx from injections. local site reaction, infx
-
Colchicine: indications, side fx, contraindications?
- used for acute gouty attacks (if safer drugs dont work)
- anti-inflammatory.
- use with caution in cardiac, renal, GI diseases
-
Allopurinol
- gout treatment
- inhibits uric acid production
- *may prolong halflife of other drugs
-
Probenecid
increases excretion of uric acid
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