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UMMC PHARM test2 Adreno

  1. Epinephrine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: Endogenous Catecholamines
    • Receptors: α1, α2, β1, β2 β3
    • T.U.: Systemic- Cardiac arrest, Anaphylaxis; Topical- adjunct to anesthetics, hemostasis, bronchial asthma, open-angle glaucoma
    • O.C.: Rapidly metabolized by MAO, orally ineffective
  2. Norepinephrine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: Endogenous Catecholamines
    • Receptors: α1, α2, β1, β3 (NOT β2)
    • T.U.: Shock with hypotension
    • O.C.: Rapidly metabolized by MAO, orally ineffective
  3. Dopamine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: Endogenous Catecholamines
    • Receptors: D1, D2, (also α1 and β1 at high levels)
    • T.U.: Increase Renal Blood Flow, Cardiogenic shock, hypovolemic shock
    • O.C.: Rapidly metabolized by MAO, orally ineffective
  4. Phenylephrine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: α1 Adrenoceptor agonist
    • Receptors: α1
    • T.U.: Severe hypotension, Paroxysmal atrial tachycardia, open-angle glaucoma, mydriasis, Nasal/Ocular decongestant
    • O.C.: Good for shock due to spinal injury or anesthesia
  5. Clonidine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: α2 Adrenoceptor agonist
    • Receptors: α2
    • T.U.: Hypertension, Drug withdrawl, Analgesia, ADHD
    • O.C.: used for CNS effects, Decreases sympathetic outflow, increases cardiac vagal tone, decreases NE release
  6. Tizanidine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: α2 Adrenoceptor agonist
    • Receptors: α2
    • T.U.: Skeletal muscle spasticity
    • O.C.: Less hypotension than clonidine, better affinity for spinal cord receptors vs vasculature
  7. Apraclonidine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: α2 Adrenoceptor agonist
    • Receptors: α2
    • T.U.: OA glaucoma
    • O.C.: may cause allergic rxn
  8. Methyldopa (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: α2 Adrenoceptor agonist (prodrug)
    • Receptors: α2
    • T.U.: Hypertension
    • O.C.: converted to α-methyl NE-selective α2 agonist
  9. Isoproterenol (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: Non-selective β Adrenoceptor agonist
    • Receptors: β1-3
    • T.U.: Shock, Bradycardia/Heart block, Bronchial Asthma
    • O.C.: Causes Skeletal muscle tremor (β2 )
  10. Dobutamine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: β1 Adrenoceptor agonist
    • Receptors: α1 β1
    • T.U.: Cardiogenic decompensation or shock
    • O.C.: catecholamine, increases inotropy without chronotropy
  11. Terbutaline (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: β2 Adrenoceptor Agonist
    • Receptors: β2
    • T.U.: Status asthmaticus, bronchospasm, asthma, COPD
    • O.C.: Resistant to MAO, COMT
  12. Ritodrine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: β2 Adrenoceptor Agonist
    • Receptors: β2
    • T.U.: Tocolytic drug (dec. uterine contraction), arrest premature labor
    • O.C.: Direct (β1 ) and reflex (β2 ) tachycardia, Hyperglycemia, muscle tremor
  13. Albuterol (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: β2 Adrenoceptor Agonist
    • Receptors: β2
    • T.U.: Bronchospasm, Asthma, COPD
    • O.C.: Resists MAO, COMT, longer duration than isoproterenol
  14. Salmeterol (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: β2 Adrenoceptor Agonist
    • Receptors: β2
    • T.U.: Nocturnal bronchospasm, Asthma maintenance therapy
    • O.C.: NOT for acute bronchospasm b/c slow onset of action and long duration of action
  15. Fenoldopam (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: D1 receptor Agonist
    • Receptors: D1
    • T.U.: Hypertensive Crises
    • O.C.: Dilates renal, mesenteric, and cerebral vessels, Acute treatment only (<48hrs)
  16. Amphetamine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: Catecholamine Releasers
    • Receptors: Causes release of NE, Epi, DA
    • T.U.: Narcolepsy, ADHD, Reversal of fatigue, Appetite suppression
    • O.C.: Resists MAO, COMT; long duration, similar potency in CNS and PNS, mixture of d and l isomers
  17. Dextroamphetamine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: Catecholamine Releasers
    • Receptors: Causes release of NE, Epi, DA
    • T.U.: Narcolepsy, ADHD, Reversal of fatigue, Appetite suppression
    • O.C.: CNS>>> PNS potency, d isomer only
  18. Methamphetamine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: Catecholamine Releasers
    • Receptors: Causes release of NE, Epi, DA
    • T.U.: Narcolepsy, ADHD, Reversal of fatigue, Appetite suppression
    • O.C.: CNS>>>PNS potency, greatest abuse potential
  19. Hydroxyamphetamine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: Catecholamine Releasers
    • Receptors: Causes release of NE, Epi, DA
    • T.U.: Diagnostic mydriasis
    • O.C.:
  20. Methylphenidate (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: Catecholamine Releasers
    • Receptors: Causes release of NE, Epi, DA
    • T.U.: Narcolepsy, ADHD drug of choice
    • O.C.:
  21. Cocaine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: NE, DA Uptake inhibitor
    • Receptors: NE or DA uptake transporter (uptake-1)
    • T.U.: ophthalmic diagnosis/surgery, Nasopharyngeal surgery
    • O.C.: Competitive inhibitor, good local anesthetic
  22. Amitriptyline (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: NE uptake inhibitor
    • Receptors: NE transporter (uptake-1)
    • T.U.: Major depression
    • O.C.: Competitive inhibitor
  23. Ephedrine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: Mixed-acting Adrenomimetic
    • Receptors: α1, α2, β1, β2
    • T.U.: Asthma (α2 ), Orthostatic hypotension, (α1 ), Nasal decongestant (α1 ), Urinary incontinence (α1 )
    • O.C.: Primary effect as agonist, also releases NE and DA, enters CNS
  24. Pseudoephedrine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: Mixed acting adrenomimetic
    • Receptors: α1, α2, β1
    • T.U.: Nasal decongestant (α1)
    • O.C.: Primary effect as agonist, slight NE and DA release as well, No CNS stimulation
  25. Phentolamine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: α Adrenoceptor Antagonist
    • Receptors: α1 α2
    • T.U.: Hypertensive crisis
    • O.C.: Competitive antagonist
  26. Phenoxybenzamine (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: α Adrenoceptor Antagonist
    • Receptors: α1 α2
    • T.U.: Pheochromocytoma, BPH
    • O.C.: Irreversible antagonist, Resistant to MAO, COMT
  27. Prazosin (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: α1 Adrenoceptor Antagonist
    • Receptors: α1
    • T.U.: Hypertension, Congestive Heart Failure
    • O.C.: Dilates arteries/Veins, decreases reflex tachycardia? Orally effective
  28. Tamsulosin (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: α1 Adrenoceptor Antagonist
    • Receptors: α1A much more than α1B
    • T.U.: BPH (urinary retention)
    • O.C.: Hypotension << prazosin
  29. Propanolol (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: β Adrenoceptor Antagonist (1st gen)
    • Receptors: β1, β2
    • T.U.: Hypertension, cardiac arrhythmias, angina, myocardial infarction
    • O.C.: High membrane stabilizing activity
  30. Timolol (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: β Adrenoceptor Antagonist (1st gen)
    • Receptors: β1, β2
    • T.U.: Pheochromocytoma, Migranes, OA glaucoma
    • O.C.:
  31. Esmolol (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: β Adrenoceptor Antagonist (2nd gen)
    • Receptors: β1 >>> β2
    • T.U.: Supraventricular tachycardia
    • O.C.: Very short duration
  32. Metoprolol (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: β Adrenoceptor Antagonist (2nd gen)
    • Receptors: β1 >>> β2
    • T.U.: Hypertensiton, Angina, Myocardial Infarction
    • O.C.:
  33. Labetalol (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: β agonist with other actions (3rd generation)
    • Receptors: β1 Antagonist, α1 Antagonist, β2 partial agonist
    • T.U.: Hypertension, Hypertensive Emergencies, Pheochromocytoma
    • O.C.:
  34. Carteolol (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: β agonist with other actions (3rd generation)
    • Receptors: β1 Antagonist, β2 Partial Agonist
    • T.U.: Hypertension, OA Glaucoma
    • O.C.: Increases vascular NO production (advantage over Timolol)
  35. Carvedilol (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: β agonist with other actions (3rd generation)
    • Receptors: β1and β2 Antagonist, α1 Antagonist
    • T.U.: Hypertension, Congestive Heart failure, Myocardial infarction
    • O.C.: Blocks VGCCs, Anti-oxident
  36. Betaxolol (Class, Receptors, Therapeutic Uses, Other Comments)
    • Class: Selective β1 antagonist with other actions (3rd generation)
    • Receptors: β1 mostly, with small β2
    • T.U.: Hypertension, OA glaucoma
    • O.C.: Blocks VGCCs, Advantage vs Timolol and carteolol
Author
sullydog101
ID
178148
Card Set
UMMC PHARM test2 Adreno
Description
UMMC PHARM test2 Adreno
Updated

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