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Epinephrine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: Endogenous Catecholamines
- Receptors: α1, α2, β1, β2 β3
- T.U.: Systemic- Cardiac arrest, Anaphylaxis; Topical- adjunct to anesthetics, hemostasis, bronchial asthma, open-angle glaucoma
- O.C.: Rapidly metabolized by MAO, orally ineffective
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Norepinephrine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: Endogenous Catecholamines
- Receptors: α1, α2, β1, β3 (NOT β2)
- T.U.: Shock with hypotension
- O.C.: Rapidly metabolized by MAO, orally ineffective
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Dopamine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: Endogenous Catecholamines
- Receptors: D1, D2, (also α1 and β1 at high levels)
- T.U.: Increase Renal Blood Flow, Cardiogenic shock, hypovolemic shock
- O.C.: Rapidly metabolized by MAO, orally ineffective
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Phenylephrine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: α1 Adrenoceptor agonist
- Receptors: α1
- T.U.: Severe hypotension, Paroxysmal atrial tachycardia, open-angle glaucoma, mydriasis, Nasal/Ocular decongestant
- O.C.: Good for shock due to spinal injury or anesthesia
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Clonidine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: α2 Adrenoceptor agonist
- Receptors: α2
- T.U.: Hypertension, Drug withdrawl, Analgesia, ADHD
- O.C.: used for CNS effects, Decreases sympathetic outflow, increases cardiac vagal tone, decreases NE release
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Tizanidine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: α2 Adrenoceptor agonist
- Receptors: α2
- T.U.: Skeletal muscle spasticity
- O.C.: Less hypotension than clonidine, better affinity for spinal cord receptors vs vasculature
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Apraclonidine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: α2 Adrenoceptor agonist
- Receptors: α2
- T.U.: OA glaucoma
- O.C.: may cause allergic rxn
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Methyldopa (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: α2 Adrenoceptor agonist (prodrug)
- Receptors: α2
- T.U.: Hypertension
- O.C.: converted to α-methyl NE-selective α2 agonist
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Isoproterenol (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: Non-selective β Adrenoceptor agonist
- Receptors: β1-3
- T.U.: Shock, Bradycardia/Heart block, Bronchial Asthma
- O.C.: Causes Skeletal muscle tremor (β2 )
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Dobutamine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: β1 Adrenoceptor agonist
- Receptors: α1 β1
- T.U.: Cardiogenic decompensation or shock
- O.C.: catecholamine, increases inotropy without chronotropy
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Terbutaline (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: β2 Adrenoceptor Agonist
- Receptors: β2
- T.U.: Status asthmaticus, bronchospasm, asthma, COPD
- O.C.: Resistant to MAO, COMT
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Ritodrine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: β2 Adrenoceptor Agonist
- Receptors: β2
- T.U.: Tocolytic drug (dec. uterine contraction), arrest premature labor
- O.C.: Direct (β1 ) and reflex (β2 ) tachycardia, Hyperglycemia, muscle tremor
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Albuterol (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: β2 Adrenoceptor Agonist
- Receptors: β2
- T.U.: Bronchospasm, Asthma, COPD
- O.C.: Resists MAO, COMT, longer duration than isoproterenol
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Salmeterol (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: β2 Adrenoceptor Agonist
- Receptors: β2
- T.U.: Nocturnal bronchospasm, Asthma maintenance therapy
- O.C.: NOT for acute bronchospasm b/c slow onset of action and long duration of action
-
Fenoldopam (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: D1 receptor Agonist
- Receptors: D1
- T.U.: Hypertensive Crises
- O.C.: Dilates renal, mesenteric, and cerebral vessels, Acute treatment only (<48hrs)
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Amphetamine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: Catecholamine Releasers
- Receptors: Causes release of NE, Epi, DA
- T.U.: Narcolepsy, ADHD, Reversal of fatigue, Appetite suppression
- O.C.: Resists MAO, COMT; long duration, similar potency in CNS and PNS, mixture of d and l isomers
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Dextroamphetamine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: Catecholamine Releasers
- Receptors: Causes release of NE, Epi, DA
- T.U.: Narcolepsy, ADHD, Reversal of fatigue, Appetite suppression
- O.C.: CNS>>> PNS potency, d isomer only
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Methamphetamine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: Catecholamine Releasers
- Receptors: Causes release of NE, Epi, DA
- T.U.: Narcolepsy, ADHD, Reversal of fatigue, Appetite suppression
- O.C.: CNS>>>PNS potency, greatest abuse potential
-
Hydroxyamphetamine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: Catecholamine Releasers
- Receptors: Causes release of NE, Epi, DA
- T.U.: Diagnostic mydriasis
- O.C.:
-
Methylphenidate (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: Catecholamine Releasers
- Receptors: Causes release of NE, Epi, DA
- T.U.: Narcolepsy, ADHD drug of choice
- O.C.:
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Cocaine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: NE, DA Uptake inhibitor
- Receptors: NE or DA uptake transporter (uptake-1)
- T.U.: ophthalmic diagnosis/surgery, Nasopharyngeal surgery
- O.C.: Competitive inhibitor, good local anesthetic
-
Amitriptyline (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: NE uptake inhibitor
- Receptors: NE transporter (uptake-1)
- T.U.: Major depression
- O.C.: Competitive inhibitor
-
Ephedrine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: Mixed-acting Adrenomimetic
- Receptors: α1, α2, β1, β2
- T.U.: Asthma (α2 ), Orthostatic hypotension, (α1 ), Nasal decongestant (α1 ), Urinary incontinence (α1 )
- O.C.: Primary effect as agonist, also releases NE and DA, enters CNS
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Pseudoephedrine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: Mixed acting adrenomimetic
- Receptors: α1, α2, β1
- T.U.: Nasal decongestant (α1)
- O.C.: Primary effect as agonist, slight NE and DA release as well, No CNS stimulation
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Phentolamine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: α Adrenoceptor Antagonist
- Receptors: α1 α2
- T.U.: Hypertensive crisis
- O.C.: Competitive antagonist
-
Phenoxybenzamine (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: α Adrenoceptor Antagonist
- Receptors: α1 α2
- T.U.: Pheochromocytoma, BPH
- O.C.: Irreversible antagonist, Resistant to MAO, COMT
-
Prazosin (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: α1 Adrenoceptor Antagonist
- Receptors: α1
- T.U.: Hypertension, Congestive Heart Failure
- O.C.: Dilates arteries/Veins, decreases reflex tachycardia? Orally effective
-
Tamsulosin (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: α1 Adrenoceptor Antagonist
- Receptors: α1A much more than α1B
- T.U.: BPH (urinary retention)
- O.C.: Hypotension << prazosin
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Propanolol (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: β Adrenoceptor Antagonist (1st gen)
- Receptors: β1, β2
- T.U.: Hypertension, cardiac arrhythmias, angina, myocardial infarction
- O.C.: High membrane stabilizing activity
-
Timolol (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: β Adrenoceptor Antagonist (1st gen)
- Receptors: β1, β2
- T.U.: Pheochromocytoma, Migranes, OA glaucoma
- O.C.:
-
Esmolol (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: β Adrenoceptor Antagonist (2nd gen)
- Receptors: β1 >>> β2
- T.U.: Supraventricular tachycardia
- O.C.: Very short duration
-
Metoprolol (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: β Adrenoceptor Antagonist (2nd gen)
- Receptors: β1 >>> β2
- T.U.: Hypertensiton, Angina, Myocardial Infarction
- O.C.:
-
Labetalol (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: β agonist with other actions (3rd generation)
- Receptors: β1 Antagonist, α1 Antagonist, β2 partial agonist
- T.U.: Hypertension, Hypertensive Emergencies, Pheochromocytoma
- O.C.:
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Carteolol (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: β agonist with other actions (3rd generation)
- Receptors: β1 Antagonist, β2 Partial Agonist
- T.U.: Hypertension, OA Glaucoma
- O.C.: Increases vascular NO production (advantage over Timolol)
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Carvedilol (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: β agonist with other actions (3rd generation)
- Receptors: β1and β2 Antagonist, α1 Antagonist
- T.U.: Hypertension, Congestive Heart failure, Myocardial infarction
- O.C.: Blocks VGCCs, Anti-oxident
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Betaxolol (Class, Receptors, Therapeutic Uses, Other Comments)
- Class: Selective β1 antagonist with other actions (3rd generation)
- Receptors: β1 mostly, with small β2
- T.U.: Hypertension, OA glaucoma
- O.C.: Blocks VGCCs, Advantage vs Timolol and carteolol
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