Bio Aging Midterm Discussion papers and Aging patterns.txt

First to determine the Type III aging pattern, doing research on oak trees (theorized from Raymond Pearl)

Dog breeding studies: showed that lifespan increases in dog breeds with larger brain:body ratio

Showed that increase in metabolic activity, along with an increase in temperature causes increase in mortality rates in houseflies

• showed that reduced calorie diet in mice showed:
• 1. Increase in % survival
• 2. Decrease in body mass
• 3. decrease in TUMOR mortality

• Carried out LARGEST study with MedFlys: showing NOT exhibiting Gompertz pattern.
• Flies had higher survival rates as age INCREASED

discovered that immortal amoebas could be transformed to 'spanned' amoebas with NUTRIENT DEPRIVATION, even briefly

• Showed Vitamin E supplementation for paramecium cells increases lifespan
• Data showed a Type I Gompertzian slope curve

• Showed castrated males vs intact had more higher life expectancy.
• Also showed mentally retarded males exhibited hyperbolic pattern of age-related mortality increase

Type I:

• Looked at British aristocracy, showed that women age of first child birth and # of children correlate with longevity of females
• Longer you wait until first child, and if only have 1 child: show longest longevity

• Using Drosophila melanogaster, show the increase in Vitamin A consumption is correlated to increase in longevity
• Too much Vit A can be detrimental, however, causing a decrease in longevity

• Type I:
• Linear curve on a semi-logarithmic mortality plot
• Concave slope on double log plot
• delta ln qx is POSITIVE and constant, so doubledelta q is ZERO (inverse Gomp w/type III shows neg delta lnqx)
• qx= qo (e)a(x)^n
• Declining life expectancy with age

• Determines how RAPID mortality rate Increases
• Thomas paper: redundancy may improve cell survivorship by reducing rate of loss of genetic info