S4M2 GI

melena
- black tarry stool from bleeding in UGI
- **req at least 60 ml and 10-14 hours**
gross section turns yellow after formalin fixation
- intestinal carcinoid
- SI>LI
flushing face, HTN, diarrhea

think carcinoid (NE tumor) secreting high levels of hormones like 5-HT
MCC of cholangiocarcinoma

liver fluke biliary infection
exposure to vinyl chloride, arsenic or thorotrast

Hempatic angiosarcoma
grossly thickened gastric wall

gastric lymphoma
APC mutation seen in ashkenazi jews

I1307K
defect in MYH associated polyposis and what cn risk increased
- DNA base-excision repair
- duodenal cn risk increased
most mutated gene in HNPCC
- MSH2 and 1 (tumor suppressor genes)
- "mismatch repair"

Author

sweetlu

175781

Card Set

S4M2 GI

Description

S4M2 GI

Updated

2012-10-13T19:14:56Z

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