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Drug
a substance not needed for survival or normal organism that effects living tissue.
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Psychoactive drug
act on central nervous system and pass the blood brain barrior. Alter consciousness, mood, perception, and behavior. Fat (lipid) soluable
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Tennents of Pharmacology #1
All drugs effect are dose dependent, magnitude, subjective experience-what it does and how it feels
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Tennents of Pharmocology # 2
- All drugs have multiple effects- main and side effects, tolerance after repeated use: need more to product desired effects, tolerance to multiple effects at different rates.
- withdrawel-unpleasant after effects-Drug/Blood level drop. opposite of initial effect, multiple
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Tennents of Parmacology
All drugs are toxic. Damage internal organs, lethal-death, safety magin LDSO-median lethal dose / EDSO median effective dose
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Neurotoxicity
damage brain cells
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Behavioral toxicity
reaction time, learning, memory, perception, coordination
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Fate of a drug- Pharmoco Kinetics
- How the drugs move through the body and effect
- Faster -> Brain effects more intense and immediate, the faster leave the body - withdrawals more intense and more immediate. more lipid soluable. have + or - charge
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Absorption
gets past skin into bloodstream-routes of adminsistration, efficiency, speed to brain and amount of loss can vary
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Topical-transdermal
- thru the skin, slow steady, incomplete,
- loss thru wash, perpiration, evaporation, embed in skin
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Oral
- absorbed thru stomach or small intestine, faster than topical, incomplete,
- loss thru-saliva, vomit, stomach acid, impact in food
- effect stomach contents-slow or speed
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Rectal
- lining of anus, faster more complete
- loss thru-leaking, gas, bowel movement
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Sublingual
- Under the tongue, as fast
- loss slavia
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Intranasal
- snort, mucus membrane, nasal cavities, faster
- Loss-mucous, sneeze, cough, pass into lungs
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Dispositional tolerance
drug slows its own absorption
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Inhalation
- vaporized thru lungs, very fast, complete
- loss injection
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IV injection
- directly into the blood stream
- complete and fastest
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