med chem quiz 4

Hypertension not controlled by diuretic and two other agents
Appears to alter Ca+2 uptake
Warning of possible caridac lesions

Long term treatment of hypertension
IV through a central catheter
Direct vasodilation of pulmonary and systemic vascular beds
T 1/2 - 6 minutes

Common names Prostacyclin & PGI2

Long term treatment of pulmonary hypertension
Sub Q - medronic minimed device
Prostaglandin analog
T 1/2 - 2-4 hours

Long term treatment of hypertension
Oral dosing
Specific and competitive antagonist of endothelin-1 receptors
Contraindicated in pregnancy
Monitor liver function

Pulmonary arterial hypertension
Inhalant
Dilates systemic and pulmonary arterial beds
Eliminated by beta-oxidation + glucuronide conjugate

Pulmonary arterial hypertension
Selective inhibitor of cyclic guanosine monophosphate specific phosphodiesterase 5
increase effects of NO
SE - abnormal color vision
known QT longation

Sildenafil for erectile dysfuncion

Tadalafil for erectile dysfunction

Pulmonary hypertension
Selective inhibitor of cyclic guanosine monophosphate specific phosphodiesterase 5
increase effects of NO
SE - Abnormal color vision
Sudden hearing loss

Endothelial receptor antagonist for type-A (ET_A) receptor
Pulmonary arterial hypertension
Oral
Substrate for P-gp, OAT, CYP3A4 & CYP2C19

Peripheral ischemia due to arterial spasm & myocardial arrhythmias
inhibits cAMP phosphodiesterase, ^ cAMP
Contraindicated in glaucoma
GI & GU spasmolytic
Old natural product isolated from plant

Possible effective against cerebral vascular insufficiency (burgers disease)
unlabeled - dysmenorrhea & threatened premature labor
Alpha adrenoceptor antagonist with beta adrenoreceptor stimulating properties
SE - palpitations & rash

Peptide derived vasodilators
IV
derived from E. coli
32 amino acid
fragment of human B-type natriuretic peptide produced by ventricular myocardium
SE - watch for patients with low cardiac filling pressure