-
octreotide
- somatostatin analog
- USES: acromegaly, prevention of gigantism, carcinoid syndrome, ruptured esophageal varices
- AE: GIT problems, gall stones, B12 deficiency, CV problems
-
bromocriptine
DA agonist D2
-
-
somatropin
recombinant human GH
-
pegvisomant
MOA: GH antagonist, decreases IGF-1, GH remains high
-
mecasermin
recombinant IGF-1
-
conivaptan
vasopressin antagonist
-
oxytocin
- induce and augment labor after cervix has ripened
- control post partum hemorrhage
- improve milk ejection
- AE: cardiac arrhythmias, CNS stimulation, excessive uterine contractions
- CI: fetal distress, abnormal fetal presentation, CPD
-
propylthiouracil
- MOA: thioamides inhibit hormone synthesis by inhibiting thyroid peroxidase
- USES: grave's disease
- short t1/2, needs to be given 2-3 times a day. reserved for use during 1st trimester, thyroid storm, and those experiencing AD
-
methimazole
- MOA: thioamides inhibit hormone synthesis by inhibiting thyroid peroxidase
- USES: graves disease
- more potent and longer acitng than propylthiouracil, single daily dose, preferred for long term tx
-
FGF23
- produced by osteocytes
- secretion is stimulated by calcitriol and increased serum PO4
- decreases renal absorption of PO4
- inhibits formation of 1,25(OH)2D
-
sevelamer
- non absorbable polymer that binds intestinal PO4 preventing its absorption and decreasing serum phosphate levels
- used in pts with renal failure on dialysis
- AE: mainly GI symptoms - N/V
-
cinacalcet
- secondary hyperparathyroidism due to chronic kidney disease
- parathyroid carcinoma
- sensitizes the CaSR to serum Ca changing the set point between the level of Ca and the rate of secretion of PTH
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