-
Levadopa
- dopaminenausea, loss of appetite, vomiting, and lowered blood pressure.
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Carbidopa
reduces the side effects of levadopa
-
Simemet
- carbidopa + Levadopa
- 25/100
- Gold Standard
- 3 – 4 x/day
- much less side effects
-
ComT inhibitor
- inhibits 3-0 methyldopa - which breaks down dopamine
- liver toxicity issues
-
Stalevo
- Simemet + ComT inhibitor
- (levadopa carbidopa entacapone)
- liver toxicity issues
-
Tasmar (tolcapone)
- ComT inhibitor
- **liver damage and failure
- dizziness, dyskinesias, GI upset, ↓b/p, sleep disorders
- don't do these right away, try sinamet first
-
Comtan (entacopone)
- ComT inhibitor
- used to manage fluctuations combined w/ sinamet
- dizziness, dyskinesias, GI upset, ↓b/p, sleep disorders
- don't do these right away, try sinamet first
-
Cogentin (benztropine)
- anticholinergic
- blocks acetylcholine so more dopamine can be absorbed
- not as affective, more side effects
- use if tremor and drooling are not otherwise controlled
- Dry mouth, nausea, blurred vision, nervousness, dizziness
-
Benadryl
effective in elderly to control drooling
-
dopamine agonists
not dopamine, but the body “thinks” it is
-
Mirapex (pramipexole)
- dopamine agonistsexcessive daytime sleepiness, low blood pressure and behavioral problems
-
Requip (ropinirole)
- dopamine agonists
- excessive daytime sleepiness, low blood pressure and behavioral problems
-
Amantadine
- anti viral
- effects a class of chemicals called catecholamines, of which dopamine is one
- beneficial for motor problems of Parkinsons
- nausea, insomnia
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